Document Detail


Complexity of intracranial pressure correlates with outcome after traumatic brain injury.
MedLine Citation:
PMID:  22734128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study applied multiscale entropy analysis to investigate the correlation between the complexity of intracranial pressure waveform and outcome after traumatic brain injury. Intracranial pressure and arterial blood pressure waveforms were low-pass filtered to remove the respiratory and pulse components and then processed using a multiscale entropy algorithm to produce a complexity index. We identified significant differences across groups classified by the Glasgow Outcome Scale in intracranial pressure, pressure-reactivity index and complexity index of intracranial pressure (P < 0.0001; P = 0.001; P < 0.0001, respectively). Outcome was dichotomized as survival/death and also as favourable/unfavourable. The complexity index of intracranial pressure achieved the strongest statistical significance (F = 28.7; P < 0.0001 and F = 17.21; P < 0.0001, respectively) and was identified as a significant independent predictor of mortality and favourable outcome in a multivariable logistic regression model (P < 0.0001). The results of this study suggest that complexity of intracranial pressure assessed by multiscale entropy was significantly associated with outcome in patients with brain injury.
Authors:
Cheng-Wei Lu; Marek Czosnyka; Jiann-Shing Shieh; Anna Smielewska; John D Pickard; Peter Smielewski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-25
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  135     ISSN:  1460-2156     ISO Abbreviation:  Brain     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-30     Completed Date:  2012-10-17     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  England    
Other Details:
Languages:  eng     Pagination:  2399-408     Citation Subset:  AIM; IM    
Affiliation:
Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB0 2QQ, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain Injuries / physiopathology*,  therapy*
Cohort Studies
Female
Glasgow Coma Scale / trends
Humans
Intracranial Pressure / physiology*
Male
Middle Aged
Prospective Studies
Retrospective Studies
Treatment Outcome
Young Adult
Grant Support
ID/Acronym/Agency:
G0600986//Medical Research Council; G9439390//Medical Research Council
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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