Document Detail

Complexity of gastric acid secretion revealed by targeted gene disruption in mice.
MedLine Citation:
PMID:  20166994     Owner:  NLM     Status:  MEDLINE    
Physiology of gastric acid secretion is one of the earliest subjects in medical research and education. Gastric acid secretion has been sometimes inadequately expressed as pH value rather than amount of gastric H(+) secreted per unit time. Gastric acid secretion is regulated by endocrine, paracrine and neurocrine signals via at least three messenger pathways: gastrin-histamine, CCK-somatostatin, and neural network. These pathways have been largely validated and further characterized by phenotyping a series of knockout mouse models. The complexity of gastric acid secretion is illustrated by both expected and unexpected phenotypes of altered acid secretion. For examples, in comparison with wild-type mice, gastrin and CCK double knockout and SSTR(2) knockout mice displayed a shift in the regulation of ECL cells from somatostatin-SSTR(2) pathway to galanin-Gal1 receptor pathway; a shift in the regulation of parietal cells from gastrin-histamine pathway to vagal pathway; and a shift in the CCK(2) receptors on parietal cells from functional silence to activation. The biological function of glycine-extended gastrin in synergizing gastrin-17 has been revealed in gastrin knockout mice. The roles of gastric acid secretion in tumorigenesis and ulceration have not been fully understood. Transgenic hypergastrinemic INS-GAS mice developed a spontaneous gastric cancer, which was associated with an impaired acid secretion. Gastrin knockout mice were still able to produce acid in response to vagal stimulation, especially after H. pylori infection. Taken together, phenotyping of a series of genetically engineered mouse models reveals a high degree of complexity of gastric acid secretion in both physiological and pathophysiological conditions.
Duan Chen; Chun-Mei Zhao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  16     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1235-40     Citation Subset:  IM    
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Laboratory Centre (3rd Floor-East Side), Erling Skjalgssons Gate 1, NO-7006 Trondheim, Norway.
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MeSH Terms
Cholecystokinin / genetics*
Gastric Acid / secretion*
Gastrins / genetics*
Gene Targeting*
Helicobacter Infections / physiopathology
Helicobacter pylori
Mice, Knockout
Paracrine Communication
Peptic Ulcer / physiopathology
Receptors, Somatostatin / genetics*
Stomach Neoplasms / etiology,  physiopathology
Reg. No./Substance:
0/Gastrins; 0/Receptors, Somatostatin; 0/Sstr2 protein, mouse; 9011-97-6/Cholecystokinin

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