| Complexes of technetium with hydroxycarboxylic acids: gluconic, glucoheptonic, tartaric, and citric. | |
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MedLine Citation:
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PMID: 7431109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Technetium complexes of several hydroxycarboxylic acids are used for medical imaging. To determine the oxidation state of technetium in these agents, we studied the reduction of pertechnetate (Tc-99) in 0.1 M solutions of four hydroxycarboxylic acids, using polarography and amperometric titration with Sn(II). In D-gluconate below pH 6, Tc(III) and Tc(V) complexes were identified with certainty, Tc(IV) questionably; at pH 6 to 10, Tc(IV) and Tc(V) were formed; above pH 10, Tc(III), Tc(IV), and Tc(V). In D-glucoheptonate below pH 6, Tc(III) and Tc(V) were formed, and questionably Tc(IV); at pH 6 to 10, Tc(V); above pH 10, Tc(III), Tc(V), and probably Tc(IV). In L-tartrate below pH 6, Tc(III), Tc(IV), and Tc(V) were formed; above pH 6, Tc(IV) and Tc(V). In citrate below pH 10, Tc(III), Tc(IV), and Tc(V) were formed; above pH 10, Tc(IV) and Tc(V). For all four ligands the initial product of reduction by Sn(II) at pH 3 to 9 was Tc(V). In freshly prepared tin-labeled imaging agents of this class, the oxidation state is probably Tc(V). Lower stable oxidation states exist, attainable by using reducing agents stronger than tin; these may show altered imaging properties. |
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Authors:
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C D Russell; A G Speiser |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 21 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1980 Nov |
Date Detail:
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Created Date: 1981-01-26 Completed Date: 1981-01-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1086-90 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carboxylic Acids* Chelating Agents* Citrates Gluconates Hydrogen-Ion Concentration Organotechnetium Compounds* Oxidation-Reduction Radionuclide Imaging / methods Sugar Acids Tartrates Technetium* Tin |
| Chemical | |
Reg. No./Substance:
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0/Carboxylic Acids; 0/Chelating Agents; 0/Citrates; 0/Gluconates; 0/Organotechnetium Compounds; 0/Sugar Acids; 0/Tartrates; 0/technetium Tc 99m gluceptate; 7440-26-8/Technetium; 7440-31-5/Tin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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