| Complexes of dichloro[2-(dimethylaminomethyl)phenyl-C1,N]gold(III), [Au(damp-C1,N)Cl2], with formylferrocene thiosemicarbazones: synthesis, structure and cytotoxicity. | |
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MedLine Citation:
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PMID: 15149809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dichloro[2-(dimethylaminomethyl)phenyl- phenyl-C1,N]gold(III), [Au(damp-C1,N)Cl2], reacts with the formylferrocene thiosemicarbazones derived from 4-methyl-, 4-phenyl-, 4-ethyl- and 4,4-dimethyl-3-thiosemicarbazides, HFcTSC, to give complexes of general formula [Au(Hdamp-1C)Cl(FcTSC)]Cl. These complexes were isolated and characterized by elemental analysis, mass spectrometry and IR, 1H NMR and (13)C NMR spectroscopy. In some cases, cyclic voltammetric studies were carried out and these showed that the complexation of gold affects the redox behaviour of the ferrocene unit. The in vitro antitumor activity against the HeLa cell line was also determined for the more soluble complexes. The IC(50) values were found to be higher than that of cisplatin but the maximum antiproliferative activity was similar. |
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Authors:
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José S Casas; María V Castaño; María C Cifuentes; Juán C García-Monteagudo; Agustín Sánchez; José Sordo; Ulrich Abram |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of inorganic biochemistry Volume: 98 ISSN: 0162-0134 ISO Abbreviation: J. Inorg. Biochem. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-19 Completed Date: 2005-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905788 Medline TA: J Inorg Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 1009-16 Citation Subset: IM |
Affiliation:
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Departamento de Química Inorgánica, Facultade de Quimica, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Galicia, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
/
chemical synthesis*,
chemistry,
toxicity* Cisplatin / toxicity Ferric Compounds / chemical synthesis*, chemistry, toxicity* Gold Compounds / chemical synthesis*, chemistry, toxicity* Hela Cells Humans Organometallic Compounds / chemical synthesis*, chemistry, toxicity* Thiosemicarbazones / chemical synthesis*, chemistry, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Ferric Compounds; 0/Gold Compounds; 0/Organometallic Compounds; 0/Thiosemicarbazones; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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