Document Detail


Complex visual manifestations of posterior cortical atrophy.
MedLine Citation:
PMID:  23196944     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT:: We describe 5 patients with complex visual disturbances in the absence of ocular pathology who were ultimately diagnosed with posterior cortical atrophy (PCA). The presence of visual cortical symptoms, neuroimaging findings and clinical evolution led to the diagnosis 1-5 years after the onset of visual symptoms. Age of onset ranged from 50-66 years. In 3 cases, magnetic resonance imaging (MRI) of the brain demonstrated predominantly right posterior cortical atrophy. The other 2 patients had nonspecific MRI findings but the diagnosis was established given the findings on clinical examination and positron emission tomography (PET). All progressed to global dementia and an autopsy confirmed the diagnosis of Alzheimer disease in one patient. The possibility of PCA should be considered when a patient presents with complex visual symptoms in the absence of ocular pathology. Early neurological assessment may avoid diagnostic delay.
Authors:
Ramon Reñé; Silvia Muñoz; Jaume Campdelacreu; Jordi Gascon-Bayarri; Imma Rico; Montserrat Juncadella; Jordi Arruga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society     Volume:  32     ISSN:  1536-5166     ISO Abbreviation:  J Neuroophthalmol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431308     Medline TA:  J Neuroophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-12     Citation Subset:  IM    
Affiliation:
Departments of Neurology-Dementia Unit (RR, JC, JGB), Neuropsychology (IR, MJ), and Ophthalmology (SM, JA), Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
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