Document Detail

Complex temporal patterns of spontaneous initiation and termination of reentry in a loop of cardiac tissue.
MedLine Citation:
PMID:  18571676     Owner:  NLM     Status:  MEDLINE    
A two-component model is developed consisting of a discrete loop of cardiac cells that circulates action potentials as well as a pacing mechanism. Physiological properties of cells such as restitutions of refractoriness and of conduction velocity are given via experimentally measured functions. The dynamics of circulating pulses and the pacer's action are regulated by two threshold relations. Patterns of spontaneous initiations and terminations of reentry (SITR) generated by this system are studied through numerical simulations and analytical observations. These patterns can be regular or irregular; causes of irregularities are identified as the threshold bistability (T-bistability) of reentrant circulation and in some cases, also phase-resetting interactions with the pacer.
H Sedaghat; M A Wood; J W Cain; C K Cheng; C M Baumgarten; D M Chan
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Publication Detail:
Type:  Journal Article     Date:  2008-05-15
Journal Detail:
Title:  Journal of theoretical biology     Volume:  254     ISSN:  1095-8541     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-18     Completed Date:  2008-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  14-26     Citation Subset:  IM    
Department of Mathematics and the Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, 23284-2014, USA.
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MeSH Terms
Action Potentials / physiology
Computer Simulation*
Heart Block / physiopathology
Heart Conduction System / physiology*
Models, Cardiovascular*
Myocardial Contraction / physiology
Tachycardia / physiopathology

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