Document Detail


Complex pathologies of angiotensin II-induced abdominal aortic aneurysms.
MedLine Citation:
PMID:  21796801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiotensin II (AngII) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of AngII into mice induces the development of abdominal aortic aneurysms (AAAs). Like human AAAs, AngII-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of AngII-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.
Authors:
Alan Daugherty; Lisa A Cassis; Hong Lu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  12     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-28     Completed Date:  2011-12-13     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  624-8     Citation Subset:  IM    
Affiliation:
Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536-0509, USA. Alan.Daugherty@uky.edu
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / metabolism*
Animals
Aortic Aneurysm, Abdominal / diagnosis*,  etiology*
Connective Tissue / metabolism
Disease Models, Animal
Disease Progression
Female
Humans
Hypercholesterolemia / metabolism
Male
Mice
Peptides / chemistry
Renin-Angiotensin System
Time Factors
Grant Support
ID/Acronym/Agency:
HL062846/HL/NHLBI NIH HHS; HL80100/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Peptides; 11128-99-7/Angiotensin II
Comments/Corrections

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