| Complex pathologies of angiotensin II-induced abdominal aortic aneurysms. | |
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MedLine Citation:
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PMID: 21796801 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin II (AngII) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of AngII into mice induces the development of abdominal aortic aneurysms (AAAs). Like human AAAs, AngII-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of AngII-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue. |
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Authors:
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Alan Daugherty; Lisa A Cassis; Hong Lu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Journal of Zhejiang University. Science. B Volume: 12 ISSN: 1862-1783 ISO Abbreviation: J Zhejiang Univ Sci B Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-28 Completed Date: 2011-12-13 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 101236535 Medline TA: J Zhejiang Univ Sci B Country: China |
Other Details:
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Languages: eng Pagination: 624-8 Citation Subset: IM |
Affiliation:
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Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536-0509, USA. Alan.Daugherty@uky.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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metabolism* Animals Aortic Aneurysm, Abdominal / diagnosis*, etiology* Connective Tissue / metabolism Disease Models, Animal Disease Progression Female Humans Hypercholesterolemia / metabolism Male Mice Peptides / chemistry Renin-Angiotensin System Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL062846/HL/NHLBI NIH HHS; HL80100/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 11128-99-7/Angiotensin II |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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