| Complex macromolecular chimeras. | |
| | |
MedLine Citation:
|
PMID: 18547108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
By combining two living polymerizations, anionic and ring opening (ROP), the following novel multiblock multicomponent linear and miktoarm star (micro-star) polymer/polypeptide hybrids (macromolecular chimeras) were synthesized: Linear, PBLL-b-PBLG-b-PS-b-PBLG-b-PBLL; 3micro-stars, (PS)2(PBLG or PBLL), (PS)(PI)(PBLG or PBLL); 4micro-stars, (PS)2[P(alpha-MeS)](PBLG or PBLL), (PS)2(PBLG or PBLL)2 [PS, polystyrene; PI, polyisoprene; P(alpha-MeS), poly(alpha-methylstyrene); PBLG, poly(gamma-benzyl-L-glutamate); and PBLL, poly(-tert-butyloxycarbonyl-L-lysine)]. The procedure involves (a) the synthesis of end- or in-chain amino-functionalized polymers, by anionic polymerization high vacuum techniques and appropriate linking chemistry and (b) the use of the amino groups for the ROP of alpha-amino acid carboxyanhydrides (NCAs). Molecular characterization revealed the high molecular weight and compositional homogeneity of the macromolecular chimeras prepared. The success of the synthesis was based mainly on the high vacuum techniques used for the ROP of NCAs, ensuring the avoidance of unwanted polymerization mechanisms and termination reactions. |
| | |
Authors:
|
Anastasis Karatzas; Hermis Iatrou; Nikos Hadjichristidis; Kyouichi Inoue; Kenji Sugiyama; Akira Hirao |
Related Documents
:
|
15918508 - Synthesis of polymeric thiazolidinediones and l-ascorbic acid towards the development o... 4547208 - Failure of lymphocytes to reexpress antigen receptors after brief interaction with a to... 15468248 - Synthesis of ab diblock copolymers by atom-transfer radical polymerization (atrp) and l... 1256448 - Hydrophobic surface properties of erythrocytes studied by affinity partition in aqueous... 1083878 - Structural requirements for arthritogenicity of peptidoglycans from staphylococcus aure... 17066368 - Determination of fourteen non-steroidal anti-inflammatory drugs in animal serum and pla... |
Publication Detail:
|
Type: Journal Article Date: 2008-06-12 |
Journal Detail:
|
Title: Biomacromolecules Volume: 9 ISSN: 1526-4602 ISO Abbreviation: Biomacromolecules Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-07-15 Completed Date: 2008-09-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
|
Languages: eng Pagination: 2072-80 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biocompatible Materials
/
chemical synthesis* Macromolecular Substances Peptides / chemistry* Polymers / chemistry* Vacuum |
| Chemical | |
Reg. No./Substance:
|
0/Biocompatible Materials; 0/Macromolecular Substances; 0/Peptides; 0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Discovery of the dual polysaccharide composition of emulsan and the isolation of the emulsion stabil...
Next Document: Two-photon absorption properties of alkynyl-conjugated pyrene derivatives.