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Complex karyotype and translocation t(4;14) define high-risk newly diagnosed multiple myeloma patients (results of CMG2002 trial).
MedLine Citation:
PMID:  22023516     Owner:  NLM     Status:  Publisher    
Abstract Prognostic impact of chromosomal abnormalities was evaluated by cIg-FISH and by classical metaphase cytogenetics in acohort of 207 newly diagnosed multiple myeloma patients who were treated with high-dose therapy followed by autologous stem cell transplantation in the CMG2002 clinical trial.Incidence of chromosomal abnormalities detected by FISH was as follows: 52.7% for del(13)(q14); 6.5% fordel(17)(p13);18.6% for t(11;14)(q13;q32); 22.8% for t(4;14) (p16;q32) and 45.7% forgain(1)(q21). Metaphase cytogenetic analysis revealed complex karyotype in 19.1% and hyperdiploidy in 21.7% patients. Overall response rate was not influenced by the presence of any studied chromosomal abnormality.Patients with complex karyotype, patients with translocation t(4;14), andpatients with gain of 1q21 locus had shorter time to progression (TTP) and overall survival (OS).Other genomic changes such as translocation t(11;14) and deletion (13q) had less impact on TTP and OS. In multivariate analysis, complex karyotype, translocation t(4;14), and ?2-microglobulin level>2.5mg/l were independent prognostic factors associated with poor overall survival. Their unfavourable prognostic impact was even more pronounced if they were present in combination.Patients with t(4;14) present together with complex karyotype had the worst prognosis with median OS of only 13.2 months, whereas patients with normal karyotype or karyotype with ?2 chromosomal changeshad the best outcome with 3-year OS of 85.9%. In conclusion, complex karyotype, gain of 1q21 region, and translocation t(4;14) are major prognostic factors associated with reduced survival of newly diagnosed multiple myeloma patients treated with autologous stem cell transplantation.
Pavel Nemec; Zuzana Zemanova; Petr Kuglik; Kyra Michalova; Jana Tajtlova; Petra Kaisarova; Alexandra Oltova; Hana Filkova; Milena Holzerova; Jana Balcarkova; Marie Jarosova; Jana Rabasova; Martina Hruba; Ivan Spicka; Evzen Gregora; Zdenek Adam; Vlastimil Scudla; Vladimir Maisnar; Miroslava Schutzova; Roman Hajek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-24
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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