| Complex hair cycle domain patterns and regenerative hair waves in living rodents. | |
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MedLine Citation:
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PMID: 18094733 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Single hair follicles go through regeneration and involution cycles. In a population, hair follicles may affect each other during anagen re-entry, thus forming propagating regenerative hair waves. We review these regenerative hair waves and complex hair cycle domains, which were recently reported in transgenic mice. Two non-invasive methods to track the propagating hair wave in large populations of hair follicles in vivo are described. We also reviewed early accounts of "hair growth patterns" from classical literature. We decipher the "behavior rules" that dictate how dynamic hair waves lead to complex hair cycle domains. In general, a single domain expands when a regenerative hair wave reaches a responsive region and boundaries form when the wave reaches a non-responsive region. As mice age, multiple hair cycle domains form, each with its own regeneration rhythm. Domain patterns can be reset by physiological events such as pregnancy and lactation. Longitudinal sections across domains show arrays of follicles in a continuum of hair cycle stages. Hair cycle domains are different from regional specificity domains. Regenerative hair waves are different from the developmental wave of newly forming hair follicles. The study provides insights into the dynamic states of adult skin and physiological regulation of organ regeneration. |
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Authors:
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Maksim V Plikus; Cheng-Ming Chuong |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 128 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-14 Completed Date: 2008-05-19 Revised Date: 2011-03-18 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 1071-80 Citation Subset: IM |
Affiliation:
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Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hair / cytology, growth & development*, physiology* Hair Follicle / cytology, growth & development*, physiology* Mice Regeneration / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR042177-14/AR/NIAMS NIH HHS; R01 AR047364-07/AR/NIAMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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