Document Detail

Complex disorder of neuronal migration in an infant with possible congenital cytomegalovirus infection.
MedLine Citation:
PMID:  8890534     Owner:  NLM     Status:  MEDLINE    
A ten-months-old girl was evaluated for developmental delay, increased muscle tone and seizures. CT and MRI revealed un uncommon combination of two different manifestations of neuronal migration disturbance: agyria/pachygyria and subcortical laminar heterotopia ("double cortex" syndrome). The occurrence of these two manifestations of neuronal migration dosorders in the same individual is quite unusual. The possible pathogenesis of such a complex disorder could probably be established only by histologic examination of the brain. A positive serologic reaction for cytomegalovirus in the infant at the age of 11 months and in the mother suggested but did not prove the cytomegalovirus infection in early gestation as the cause of the disorder.
D Mardesić; Z Sucić; J Papa; I Senecić; V Sarnavka; D Skarpa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti     Volume:  50     ISSN:  1330-0164     ISO Abbreviation:  Acta Med Croatica     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9208249     Medline TA:  Acta Med Croatica     Country:  CROATIA    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
University Department of Pediatrics, University Hospital Center, Sveti Duh General Hospital, Zagreb, Croatia.
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MeSH Terms
Brain / abnormalities*,  embryology,  radiography
Cytomegalovirus Infections / complications,  congenital*
Magnetic Resonance Imaging
Tomography, X-Ray Computed

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