| Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy. | |
| | |
MedLine Citation:
|
PMID: 20735354 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Drugs derived from natural resources represent a significant segment of the pharmaceutical market as compared to randomly synthesized compounds. It is a goal of drug development programs to design selective ligands that act on single disease targets to obtain highly effective and safe drugs with low side effects. Although this strategy was successful for many new therapies, there is a marked decline in the number of new drugs introduced into clinical practice over the past decades. One reason for this failure may be due to the fact that the pathogenesis of many diseases is rather multi-factorial in nature and not due to a single cause. Phytotherapy, whose therapeutic efficacy is based on the combined action of a mixture of constituents, offers new treatment opportunities. Because of their biological defence function, plant secondary metabolites act by targeting and disrupting the cell membrane, by binding and inhibiting specific proteins or they adhere to or intercalate into RNA or DNA. Phytotherapeutics may exhibit pharmacological effects by the synergistic or antagonistic interaction of many phytochemicals. Mechanistic reasons for interactions are bioavailability, interference with cellular transport processes, activation of pro-drugs or deactivation of active compounds to inactive metabolites, action of synergistic partners at different points of the same signalling cascade (multi-target effects) or inhibition of binding to target proteins. "-Omics" technologies and systems biology may facilitate unravelling synergistic effects of herbal mixtures. |
| | |
Authors:
|
Thomas Efferth; Egon Koch |
Related Documents
:
|
20199394 - Intraarticular treatments for osteoarthritis: new perspectives. 18991604 - Discovering new schistosome drug targets: the role of transcriptomics. 20483274 - Discovering drug targets through the web. 20490984 - Leveraging molecular heterogeneity of the vascular endothelium for targeted drug delive... 1573044 - Comparative drug effects and abuse liability of lorazepam, buspirone, and secobarbital ... 7213494 - Studies on the responses of isolated intestine of the giant african land snail (archach... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current drug targets Volume: 12 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 122-32 Citation Subset: IM |
Affiliation:
|
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. efferth@uni-mainz.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prostanoid receptors as possible targets for anti-allergic drugs: recent advances in prostanoids on ...
Next Document: Golgi apparatus fragmentation as a mechanism responsible for uniform delivery of uroplakins to the a...