| Complex fractionated electrograms and AF nests in vagally mediated atrial fibrillation. | |
| | |
MedLine Citation:
|
PMID: 20636313 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Catheter ablation targeting of complex fractionated atrial electrograms (CFAEs) is one of the techniques used for atrial fibrillation (AF) ablation. The ablation of sites showing a high-frequency spectral component (HFC) during sinus rhythm, known as AF nests, has been introduced as an adjunct to conventional ablation. Known locations of some AF nests are similar to CFAE sites. However, it has not been systematically evaluated whether these two targets represent the same foci. The purpose of this study was to compare the anatomical locations of these sites using an animal model of vagally mediated AF. METHODS: Five anesthetized open-chest dogs were evaluated. Atrial electrograms were obtained epicardially. AF was induced by burst atrial pacing with 20 Hz during vagal stimulation. A total of 15 sites (eight sites in right atrium and seven sites in left atrium) were evaluated in each animal. The CFAE was determined during AF according to the electrogram patterns. After sinus conversion, real-time spectrum analysis was used for AF nest assessment at the same location. RESULTS: The CFAE was observed at the high and mid sulcus terminalis areas, pulmonary vein antrum, and mid portion of the coronary sinus. Among them, only 60% of the CFAE sites showed HFC during sinus rhythm. In addition, some of the non-CFAE sites (22%) showed HFC during sinus rhythm. CONCLUSION: The CFAE sites were not the same as the AF nests in this animal model of vagally mediated AF. Therefore, these two types of ablation methods appear to target different substrates of AF. |
| | |
Authors:
|
Seil Oh; Hyoun-Joong Kong; Eue-Keun Choi; Hee Chan Kim; Yun-Shik Choi |
Related Documents
:
|
19481103 - Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes... 15851153 - Mechanisms of recurrent atrial fibrillation after pulmonary vein isolation by segmental... 9431483 - Transcutaneous electrical nerve stimulation in unstable angina pectoris. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pacing and clinical electrophysiology : PACE Volume: 33 ISSN: 1540-8159 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1497-503 Citation Subset: IM |
Copyright Information:
|
©2010, The Authors. Journal compilation ©2010 Wiley Periodicals, Inc. |
Affiliation:
|
Seoul National University Hospital Cardiovascular Center, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. seil@snu.ac.kr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Catheter ablation of electrical storm due to monomorphic ventricular tachycardia in patients with no...
Next Document: Inhibition of the renin-angiotensin system for prevention of atrial fibrillation.