Document Detail


Completion pneumonectomy for patients with recurrent lung cancer: the impact of microvessel density on outcome.
MedLine Citation:
PMID:  10664335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effectiveness of performing completion pneumonectomy (CP) to treat recurrent lung cancer was assessed in 11 patients, 6 of whom had intrapulmonary recurrence, and 5, locoregional recurrence. The pathological types of cancer were adenocarcinoma in 5 patients, squamous cell carcinomas in 5 patients, and adenoid cystic carcinoma in 1 patient. The pathological stages of the recurrent lung cancer were stage I in 8 patients, stage II in 2 patients, and stage IV in 1 patient. The microvessels in the tumors were also examined and the results compared with those in the microvessels of 61 nonrecurrent tumors. The 1- and 3-year overall survival rates after CP were 54.5% and 27.3%, respectively. The vessel densities within primary and correspondent recurrent tumors were able to be assessed in 9 patients and found to be significantly greater compared with the mean value for the nonrecurrent tumors (P < 0.0001). The vessel densities in the primary and recurrent tumors of 2 of 3 long-term survivors were found to be relatively low. These results indicate the high-grade malignant potential of recurrent tumors, which led us to conclude that the use of CP should be carefully evaluated in patients with recurrence. Assessing the vasculature in primary tumors may be a useful indicator for determining which patients could benefit from CP.
Authors:
Y Ohta; T Hara; Y Tanaka; S Watanabe; M Oda; S Murakami; Y Watanabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery today     Volume:  30     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2000  
Date Detail:
Created Date:  2000-04-12     Completed Date:  2000-04-12     Revised Date:  2006-08-03    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  134-8     Citation Subset:  IM    
Affiliation:
First Department of Surgery, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa 920-8641, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / blood supply*,  mortality,  pathology,  surgery
Aged
Carcinoma, Adenoid Cystic / blood supply*,  mortality,  pathology,  surgery
Carcinoma, Squamous Cell / blood supply*,  mortality,  pathology,  surgery
DNA, Neoplasm / analysis
Female
Humans
Lung Neoplasms / blood supply*,  mortality,  pathology,  surgery
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Neovascularization, Pathologic / pathology*
Ploidies
Pneumonectomy*
Prognosis
Chemical
Reg. No./Substance:
0/DNA, Neoplasm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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