Document Detail


Completeness of revascularization for multivessel coronary artery disease and its effect on one-year outcome: a report from the NHLBI Dynamic Registry.
MedLine Citation:
PMID:  17880334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When percutaneous coronary intervention (PCI) is performed in patients with multivessel coronary disease, a targeted revascularization (TR) of diseased vessels is performed more often than complete revascularization (CR). We compared baseline characteristics and 1-year outcomes of patients undergoing TR by operator choice (n = 1,091), TR because CR was unachievable (n = 375), and CR (n = 315) in the National Heart, Lung, and Blood Institute (NHLBI) Dynamic Registry. Patients receiving TR because CR was unachievable were older, had more comorbidities, worse ejection fraction, less often received 2b/3a inhibitors and stents, and less frequently achieved complete angiographic success than either patients receiving TR by choice or CR. Despite these considerable differences, cumulative rates of 1-year mortality, the need for repeat PCI, or coronary bypass surgery were similar in patients who received CR, TR by choice, or TR because CR was unachievable. In multivariable models, after adjustment for clinical characteristics and propensity to receive CR, the hazard ratio for CR versus TR was 1.10 (95% CI: 0.58-2.10) for 1-year mortality; 0.89 (0.60-1.32) for repeat PCI, and 0.92 (0.66-1.29) for repeat PCI or coronary bypass surgery. In conclusion, despite the presence of more unfavorable characteristics, patients undergoing TR demonstrate 1-year outcomes equivalent to those having CR, supporting its continued use in selected patients.
Authors:
Vankeepuram S Srinivas; Faith Selzer; Robert L Wilensky; David R Holmes; Howard A Cohen; E Scott Monrad; Alice K Jacobs; Sheryl F Kelsey; David O Williams; Kevin E Kip;
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  20     ISSN:  0896-4327     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  373-80     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Montefiore Medical Center, New York, NY 10461, USA. vsriniva@montefiore.org
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Transluminal, Percutaneous Coronary / methods*
Coronary Artery Disease / therapy*
Coronary Vessels / pathology*
Female
Humans
Male
Middle Aged
Myocardial Infarction
Myocardial Revascularization / methods*
National Heart, Lung, and Blood Institute (U.S.)
Prospective Studies
Registries
Risk Factors
Severity of Illness Index
Stroke Volume
Treatment Outcome*
United States
Grant Support
ID/Acronym/Agency:
HL33292-14/HL/NHLBI NIH HHS; HL33292-16/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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