Document Detail

Completeness and accuracy of interview data from proxy respondents: demographic, medical, and life-style factors.
MedLine Citation:
PMID:  8172996     Owner:  NLM     Status:  MEDLINE    
To evaluate the quality of exposure data provided by proxy respondents, we used a dual interview protocol in a case-control study of subarachnoid hemorrhage. All control subjects and their proxy respondents were interviewed (N = 283 control-proxy pairs), as were the cases who were able to provide their own information and their proxy respondents (N = 68 case-proxy pairs). The reliability of proxy-derived data was excellent for demographic and body habitus measures (kappa or intraclass correlation range = 0.86-0.99), and all aspects of cigarette smoking history (range = 0.79-0.93). Proxy reliability was somewhat lower for questions regarding medications and hormone preparations (range = 0.55-0.88), alcohol consumption (range = 0.52-0.82), and recreational physical activity (range = 0.55-0.67). Proxy reliability varied according to the relationship of the proxy to the index subject. Relative to the index subjects, proxy respondents tended to underreport the presence or level of exposure. For most exposures, odds ratios computed with proxy-derived data were similar in magnitude to odds ratios obtained with index subject data; important bias due to differential nonresponse or differential misclassification was suggested only for questions regarding hormone replacement therapy. Epidemiologic studies that rely on proxy respondents may require more subjects to offset the effect of nondifferential nonresponse and misclassification on the precision of effect estimates.
L M Nelson; W T Longstreth; T D Koepsell; H Checkoway; G van Belle
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  5     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-06-06     Completed Date:  1994-06-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-17     Citation Subset:  IM    
Neuroepidemiology Group, University of Washington, Seattle.
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MeSH Terms
Bias (Epidemiology)
Case-Control Studies
Data Collection / standards
Effect Modifiers (Epidemiology)*
Epidemiologic Methods*
Life Style*
Middle Aged
Reproducibility of Results
Subarachnoid Hemorrhage / epidemiology,  etiology
Washington / epidemiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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