Document Detail

Completely autologous platelet gel in breast reduction surgery: a blinded, randomized, controlled trial.
MedLine Citation:
PMID:  17496586     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The objective of this study was to assess the effectiveness of topical application of completely autologous platelet gel during breast surgery to reduce postoperative wound drainage. An increasing number of surgical centers are using tissue sealants to reduce postoperative drainage and improve surgical outcomes. However, there is a paucity of randomized, double-blind, controlled trials assessing the efficacy of these agents.
METHODS: The authors conducted a within-patient, randomized, patient- and assessor-blinded, controlled trial assessing the use of completely autologous platelet gel in 111 patients undergoing bilateral reduction mammaplasty. Patients were randomized to receive the gel applied to the left or right breast after hemostasis was achieved; the other breast received no treatment. The primary outcome was the difference in wound drainage over 24 hours. Secondary outcomes included subjective and objective assessments of pain and wound healing.
RESULTS: No statistically significant differences in the drainage, level of pain, size of open areas, clinical appearance, degree of scar pliability, or scar erythema were noted.
CONCLUSION: The authors' results do not support the use of completely autologous platelet gel to improve outcomes after reduction mammaplasty.
Alexander Anzarut; Craig R Guenther; David C Edwards; Ross T Tsuyuki
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  119     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-07-02     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1159-66     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Topical
Blood Platelets*
Double-Blind Method
Follow-Up Studies
Intraoperative Care / methods
Mammaplasty / methods*
Middle Aged
Pain, Postoperative / prevention & control
Postoperative Complications / prevention & control*
Reference Values
Statistics, Nonparametric
Transplantation, Autologous
Treatment Outcome
Wound Healing / drug effects*,  physiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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