| Complete reversibility of physiological coronary vascular abnormalities in hypertrophied hearts produced by pressure overload in the rat. | |
| | |
MedLine Citation:
|
PMID: 2525568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Using an experimental model of ascending aortic banding in the rat, we examined whether coronary circulation abnormalities in hypertrophied hearts are reversible after debanding. 4-wk banding produced significant increases in in vivo left ventricular (LV) pressure (194 +/- 13 vs. 114 +/- 9 mmHg in shamoperated controls) and LV dry wt/body wt (48 +/- 5% above controls). In isolated hearts perfused with Krebs-Henseleit buffer, coronary flow rate (CFR) was estimated under nonworking conditions. During maximal vasodilation after 1 min-ischemia, CFR at a coronary perfusion pressure (CPP) of 100 mmHg and CFR/myocardidial mass at CPPs of 100 and 150 mmHg decreased significantly (72 +/- 5%; 53 +/- 4 and 61 +/- 4% of controls). 1 or 4 wk after debanding, LV systolic pressures were similar to control values, and the degree of myocardial hypertrophy decreased to levels 23 +/- 6 (P less than 0.01) and 11 +/- 6% (P less than 0.01) above their control values, respectively. At 1 wk there was no significant increase in CFR/myocardial mass, compared to values in the banded group (67 +/- 8 vs. 53 +/- 4% of controls at 100 mmHg and 67 +/- 9 vs. 61 +/- 4% at 150 mmHg of CPP). At 4 wk, CFR and the ratio had increased toward normal. Thus, decreased coronary perfusion in hypertrophied hearts is completely reversible. |
| | |
Authors:
|
S Isoyama; N Ito; M Kuroha; T Takishima |
Related Documents
:
|
1261588 - On the mechanism of the coronary dilator effect of serotonin in the dog. 1825648 - Effect of age on coronary circulation after imposition of pressure-overload in rats. 12822638 - Controlled intermittent asystole cardiac therapy induced by pharmacologically potentiat... 9787278 - Postexercise systolic blood pressure response: clinical application to the assessment o... 11941058 - Hemodynamic responses to ect after bilateral adrenalectomy. 7628688 - Angiotensin i- and ii- and norepinephrine-mediated pressor responses in an ancient holo... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of clinical investigation Volume: 84 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1989 Jul |
Date Detail:
|
Created Date: 1989-08-03 Completed Date: 1989-08-03 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 288-94 Citation Subset: AIM; IM |
Affiliation:
|
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta / physiopathology Blood Pressure* Body Weight Cardiomegaly / physiopathology* Coronary Circulation* Hemodynamics Male Organ Size Rats Rats, Inbred Strains |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calc...
Next Document: The relationship between cluster and liquid simplification and sentence length, age, and IQ in Down'...