| Complete response of metastasized adrenal cortical carcinoma with o,p'-DDD. Case report and literature review. | |
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MedLine Citation:
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PMID: 6360329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study concerns the history of a male patient with hormone-producing adrenal cortical carcinoma. Six months after resection of the primary tumor, lymph node metastases were detected and treatment with o,p'-DDD [1,1 dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane] (Lysodren/mitotane) was started. After 2 years, a complete histologically proven response was confirmed at laparotomy and is still sustained 2 years after the discontinuation of treatment. As a consequence of insufficient steroid replacement the patient suffered bouts of adrenal insufficiency. After 1 year of treatment, the measurement of the plasma levels of o,p'-DDD showed an accumulation of the drug. At that time, progressive major central nervous system toxicity occurred, which proved to be reversible on discontinuation of the treatment. |
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Authors:
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E Boven; J B Vermorken; H van Slooten; H M Pinedo |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Cancer Volume: 53 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-02-21 Completed Date: 1984-02-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 26-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex
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drug effects Adrenal Gland Neoplasms / drug therapy*, surgery Carcinoma / drug therapy*, surgery Humans Laparotomy Lymphatic Metastasis Male Middle Aged Mitotane / blood, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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53-19-0/Mitotane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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