Document Detail


Complete response of metastasized adrenal cortical carcinoma with o,p'-DDD. Case report and literature review.
MedLine Citation:
PMID:  6360329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study concerns the history of a male patient with hormone-producing adrenal cortical carcinoma. Six months after resection of the primary tumor, lymph node metastases were detected and treatment with o,p'-DDD [1,1 dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane] (Lysodren/mitotane) was started. After 2 years, a complete histologically proven response was confirmed at laparotomy and is still sustained 2 years after the discontinuation of treatment. As a consequence of insufficient steroid replacement the patient suffered bouts of adrenal insufficiency. After 1 year of treatment, the measurement of the plasma levels of o,p'-DDD showed an accumulation of the drug. At that time, progressive major central nervous system toxicity occurred, which proved to be reversible on discontinuation of the treatment.
Authors:
E Boven; J B Vermorken; H van Slooten; H M Pinedo
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cancer     Volume:  53     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-02-21     Completed Date:  1984-02-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  26-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex / drug effects
Adrenal Gland Neoplasms / drug therapy*,  surgery
Carcinoma / drug therapy*,  surgery
Humans
Laparotomy
Lymphatic Metastasis
Male
Middle Aged
Mitotane / blood,  therapeutic use*
Chemical
Reg. No./Substance:
53-19-0/Mitotane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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