Document Detail


Complete response of an HIV negative gastric Kaposi's sarcoma (KS) patient with peritoneal carcinomatosis by liposomal daunorubicin treatment.
MedLine Citation:
PMID:  11300338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the first case of an HIV negative patient with gastric Kaposi's sarcoma (KS) and peritoneal carcinomatosis in whom a complete response (CR) was obtained after liposomal daunorubicin administration. The patient presented with epigastric pain and hematemesis. Upper gastric endoscopy with multiple biopsies showed gastric involvement by KS. The whole physical examination and the thoraco-abdomino-pelvic CT scans showed no other localization. A total gastrectomy was performed. Histological examination confirmed the diagnosis of KS with involvement of regional lymph nodes and peritoneal lesions. Six cycles of liposomal daunorubicin were given. Post-treatment coelioscopic control was normal. The patient received another six adjuvant cycles of liposomal daunorubicin. The patient is in complete remission six months after the end of treatment. Liposomal daunorubicin is a promising treatment in the non HIV patient with visceral KS.
Authors:
A Fléchon; C Lombard-Bohas; J Boulez; J Y Blay; J Y Scoazec
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of oncology : official journal of the European Society for Medical Oncology / ESMO     Volume:  12     ISSN:  0923-7534     ISO Abbreviation:  Ann. Oncol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-04-12     Completed Date:  2001-09-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007735     Medline TA:  Ann Oncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  275-6     Citation Subset:  IM    
Affiliation:
Oncologie Médicale, H pital Edouard Herriot, Lyon, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibiotics, Antineoplastic / administration & dosage*
Carcinoma / drug therapy*,  etiology
Daunorubicin / administration & dosage*
HIV Seronegativity
Humans
Liposomes
Male
Peritoneal Neoplasms / drug therapy*,  etiology
Sarcoma, Kaposi / drug therapy*,  etiology
Stomach Neoplasms / drug therapy*,  etiology
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Liposomes; 20830-81-3/Daunorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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