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Complete regression of myocardial involvement associated with lymphoma following chemotherapy.
MedLine Citation:
PMID:  24109501     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Cardiac involvement as an initial presentation of malignant lymphoma is a rare occurrence. We describe the case of a 26 year old man who had initially been diagnosed with myocardial infiltration on an echocardiogram, presenting with a testicular mass and unilateral peripheral facial paralysis. On admission, electrocardiograms (ECG) revealed negative T-waves in all leads and ST-segment elevation in the inferior leads. On two-dimensional echocardiography, there was infiltration of the pericardium with mild effusion, infiltrative thickening of the aortic walls, both atria and the interatrial septum and a mildly depressed systolic function of both ventricles. An axillary biopsy was performed and reported as a T-cell lymphoblastic lymphoma (T-LBL). Following the diagnosis and staging, chemotherapy was started. Twenty-two days after finishing the first cycle of chemotherapy, the ECG showed regression of T-wave changes in all leads and normalization of the ST-segment elevation in the inferior leads. A follow-up Two-dimensional echocardiography confirmed regression of the myocardial infiltration. This case report illustrates a lymphoma presenting with testicular mass, unilateral peripheral facial paralysis and myocardial involvement, and demonstrates that regression of infiltration can be achieved by intensive chemotherapy treatment. To our knowledge, there are no reported cases of T-LBL presenting as a testicular mass and unilateral peripheral facial paralysis, with complete regression of myocardial involvement.
Authors:
Juan Pablo Vinicki; Tomás F Cianciulli; Gustavo A Farace; María C Saccheri; Jorge A Lax; Lucía R Kazelian; Adolfo Wachs
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of cardiology     Volume:  5     ISSN:  1949-8462     ISO Abbreviation:  World J Cardiol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-10     Completed Date:  2013-10-10     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  101537090     Medline TA:  World J Cardiol     Country:  China    
Other Details:
Languages:  eng     Pagination:  364-8     Citation Subset:  -    
Affiliation:
Juan Pablo Vinicki, Gustavo A Farace, Adolfo Wachs, Department of Internal Medicine, Hospital of the Government of the City of Buenos Aires "Dr. Cosme Argerich", Buenos Aires, C1155AHD, Argentina.
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