Document Detail

Complete regression of advanced liposarcoma of the anterior chest wall with interferon-alpha and tumor necrosis factor-alpha.
MedLine Citation:
PMID:  8476203     Owner:  NLM     Status:  MEDLINE    
This paper reports a case of complete regression of a liposarcoma in a 62-year-old Japanese man who, in August 1986, presented with a giant subcutaneous tumor of the right anterior chest wall. Local radiotherapy and conventional chemotherapy were initially performed; however, the tumor did not respond at all. He then received cytokine treatment (interferon-alpha and tumor necrosis factor-alpha). Nineteen months after cytokine treatment, the mass disappeared totally. The patient has been in complete remission for five years without recurrence and with no additional treatment. This suggests that the use of interferon-alpha and tumor necrosis factor-alpha in combination may be an effective and promising modality for liposarcomas which are refractory to the conventional anticancer treatments.
H Iwagaki; A Hizuta; T Yoshino; T Mannami; F Moriyasu; N Tanaka; K Orita
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  13     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1993 Jan-Feb
Date Detail:
Created Date:  1993-05-18     Completed Date:  1993-05-18     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  13-5     Citation Subset:  IM    
First Department of Surgery, Okayama University Medical School, Japan.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Interferon-alpha / administration & dosage
Liposarcoma / drug therapy*
Middle Aged
Thoracic Neoplasms / drug therapy*
Tumor Necrosis Factor-alpha / administration & dosage
Reg. No./Substance:
0/Interferon-alpha; 0/Tumor Necrosis Factor-alpha

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