Document Detail


Complete mesocolic excision in colorectal cancer: a systematic review.
MedLine Citation:
PMID:  25283236     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: Several studies have suggested an increased lymph node yield, reduced loco-regional recurrence and increased disease-free survival (DFS) after complete mesocolic excision (CME) for colorectal cancer. This review was undertaken to assess the use of CME for colon cancer by evaluating the technique and its clinical outcome.
METHOD: A literature search of publications was performed using Pubmed and Medline. Only studies published in English were included. Studies assessed for quality and data were extracted by two independent reviewers. Endpoints included numbers of lymph nodes per patient, quality of the plane of mesocolic excision, postoperative mortality and morbidity, 5 year locoregional recurrence and 5-year cancer-specific survival.
RESULTS: There were 34 articles comprising 12 retrospective studies, nine prospective studies, 13 original articles including case series, observational studies and editorials. Of the prospective studies, four reported an increased lymph node harvest and a survival benefit. The others reported an improvement in the quality of the specimen as assessed by histopathological examination. Laparoscopic CME has the same oncological outcome when compared with open surgery but completeness of excision during laparoscopy may be compromised for tumours in the transverse colon.
CONCLUSION: Studies demonstrate that CME removes significantly more tissue around the tumour including maximal lymph node clearance. There is little information on serious adverse events after CME and a long-term survival benefit has not been proven. This article is protected by copyright. All rights reserved.
Authors:
Christos Kontovounisios; James Kinross; Emile Tan; Gina Brown; Shahnawaz Rasheed; Paris Tekkis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-5
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  -     ISSN:  1463-1318     ISO Abbreviation:  Colorectal Dis     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-6     Completed Date:  -     Revised Date:  2014-10-7    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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