| Complete heart block with ventricular asystole during left vagus nerve stimulation for epilepsy. | |
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MedLine Citation:
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PMID: 15380133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vagus nerve stimulation (VNS) is an important therapeutic option for individuals with refractory epilepsy who have failed multiple antiepileptic drugs (AEDs). The intricate relationship of the vagus nerve to cardiac function raises concern that vagal stimulation may affect cardiac rhythm and function. Previous pre- and postmarketing studies have not shown this to be a significant problem, with the incidence of bradyarrhythmias reported to be about 0.1%. We review three cases of ventricular asystole with complete heart block that occurred during intraoperative lead tests. The purpose of these case reports is to identify the specific type of cardiac abnormality associated with vagus nerve stimulation and to identify individuals at risk. |
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Authors:
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Imran I Ali; Noor A Pirzada; Yousuf Kanjwal; Braxton Wannamaker; Azedine Medhkour; Michael T Koltz; Bradley V Vaughn |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Epilepsy & behavior : E&B Volume: 5 ISSN: 1525-5050 ISO Abbreviation: Epilepsy Behav Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-21 Completed Date: 2004-11-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: United States |
Other Details:
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Languages: eng Pagination: 768-71 Citation Subset: IM |
Affiliation:
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Department of Neurology, Medical College of Ohio, Toledo, OH 43614, USA. iali@mco.edu <iali@mco.edu> |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticonvulsants / therapeutic use Diabetes Complications Drug Resistance Electric Stimulation Therapy / adverse effects*, instrumentation Electrodes, Implanted Epilepsy / complications*, therapy* Heart Arrest / etiology* Heart Block / etiology* Humans Hypertension / complications Male Vagus Nerve / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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