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Complete genome sequence and molecular characterization of thermostable Newcastle disease virus strain TS09-C.
MedLine Citation:
PMID:  23296874     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A thermostable avirulent Newcastle disease virus (NDV) strain TS09-C was developed by serial passage of V4 strain in BHK-21 cells. The complete genome sequence of strain TS09-C was determined and compared with the sequences of other NDV isolates representing different thermostable phenotypes. The TS09-C genome was 15,186 nucleotides long and consisted of eight genes in the order of 3'-NP-P/V/W-M-F-HN-L-5'. High levels of nucleotide and amino acid sequence identity existed among the thermostable NDV isolates. Thermostable strains TS09-C, V4, I-2, and Ulster all belonged to genotype I. The F protein cleavage site of strain TS09-C was (112)G-K-Q-R-R-L(117), with an isolated basic amino acid and a pair of contiguous basic amino acids, differing from that of its parental V4 strain ((112)G-K-Q-G-R-L(117)). Our characterization of the complete genome of thermostable avirulent NDV strain TS09-C may facilitate the development of a thermostable NDV reverse genetic system and further study of the mechanism of thermostability of NDV.
Authors:
Guoyuan Wen; Yu Shang; Jing Guo; Chen Chen; Huabin Shao; Qingping Luo; Jun Yang; Hongling Wang; Guofu Cheng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  Virus genes     Volume:  -     ISSN:  1572-994X     ISO Abbreviation:  Virus Genes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803967     Medline TA:  Virus Genes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Animal Husbandry and Veterinary Sciences, Hubei Academy of Agricultural Sciences, Wuhan, 430072, China, wgy_524@163.com.
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