Document Detail

Complete genome sequence analysis of a natural reassortant infectious bursal disease virus in China.
MedLine Citation:
PMID:  23043174     Owner:  NLM     Status:  MEDLINE    
A novel isolate of infectious bursal disease virus (IBDV) was designated GX-NN-L. The GX-NN-L IBDV was a very virulent infectious bursal disease virus (vvIBDV) isolated from broiler flocks in Guangxi province, China, in 2011. The GX-NN-L IBDV caused high mortality, immunosuppression, low weight gain, and bursal atrophy in commercial broilers. Here, we report the complete genome sequence of the GX-NN-L IBDV, a reassortment strain with segments A and B derived from very virulent strains and attenuated IBDV, respectively. These findings from this study provide additional insights into the genetic exchange between attenuated and very virulent strains of IBDV and continuous monitoring of the spread of the virus in chicken.
Feng Chen; Jiajia Liu; Zhuanqiang Yan; Di Liu; Jun Ji; Jianping Qin; Haiyan Li; Jingyun Ma; Yingzuo Bi; Qingmei Xie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of virology     Volume:  86     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-01-07     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11942-3     Citation Subset:  IM    
College of Animal Science, South China Agricultural University, Tianhe District, Guangzhou, Guangdong, People's Republic of China.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/JX134485;  JX134486
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MeSH Terms
Atrophy / pathology
Birnaviridae Infections / mortality,  veterinary,  virology
Body Weight
Bursa of Fabricius / pathology
Genome, Viral*
Immune Tolerance
Infectious bursal disease virus / genetics*,  isolation & purification,  pathogenicity
Molecular Sequence Data
Poultry Diseases / mortality,  virology
RNA, Viral / genetics*
Reassortant Viruses / genetics*,  isolation & purification,  pathogenicity
Sequence Analysis, DNA*
Survival Analysis
Reg. No./Substance:
0/RNA, Viral
Erratum In:
J Virol. 2013 Feb;87(4):2373

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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