Document Detail

Complete failed fertilization after intracytoplasmic sperm injection--analysis of 10 years' data.
MedLine Citation:
PMID:  16405104     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate incidence and causes of complete failed fertilization after intracytoplasmic sperm injection (ICSI) in a tertiary care facility. METHODS: A total of 1,779 cycles between February 1994 and December 2003 were analyzed. Study parameters were female age, infertility diagnosis, ovarian stimulation protocol, estradiol level on day of hCG administration, number of follicles, number of oocytes retrieved, number of oocytes injected, and semen parameters. RESULTS: Complete failed fertilization occurred in 23 cycles (1.29%) involving a total of 85 oocytes injected. Infertility causes among patients with failed fertilization included unexplained (43.6%), male factor (26%), presence of more than one factor (17.4%), hysterectomy (4.4%), premature ovarian failure (4.3%), and advanced age (4.3%). In 12 cycles (52%), fewer than 5 follicles were present. In three (13%) cycles, no mature (MII) oocyte was available and in 61% (14/23) fewer than 3 MII oocytes were available for ICSI. Immotile sperm was used for ICSI in 5 cycles (21.7%). The source of sperm in 17 (74%) cycles was from ejaculate, in 4 cycles from testicular aspiration (TESA), one from percutaneous epididymal sperm aspiration (PESA) and one from retrograde ejaculation. CONCLUSIONS: Our data indicate that major contributing factors to failed fertilization after intracytoplasmic sperm injection are number of MII oocytes retrieved and availability of viable sperm for injection. Although the incidence of complete failed fertilization is not remarkable, it may increase with increasing patient age and a lower number of follicles.
Navid Esfandiari; Murid H Javed; Lynda Gotlieb; Robert F Casper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of fertility and women's medicine     Volume:  50     ISSN:  1534-892X     ISO Abbreviation:  Int J Fertil Womens Med     Publication Date:    2005 Jul-Aug
Date Detail:
Created Date:  2006-01-12     Completed Date:  2006-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706778     Medline TA:  Int J Fertil Womens Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
IVF Clinical and Research Laboratory, Toronto Centre for Advanced Reproductive Technology (TCART), Toronto, ON, Canada.
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MeSH Terms
Fertilization in Vitro / statistics & numerical data
Infertility, Female / therapy*
Preimplantation Diagnosis / statistics & numerical data
Retrospective Studies
Sperm Injections, Intracytoplasmic / statistics & numerical data*
Treatment Failure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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