Document Detail

Complete chorioamniotic membrane separation with fetal restrictive dermopathy in two consecutive pregnancies.
MedLine Citation:
PMID:  17286315     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe an instance of complete chorion-amnion membrane separation with fetal restrictive dermopathy in two consecutive pregnancies. METHODS: We performed prenatal ultrasounds in two consecutive pregnancies and evaluated gross and microscopic postnatal findings. RESULTS: The first pregnancy ended at 32 weeks of gestation with spontaneous chorioamniotic membrane separation and preterm premature rupture of membranes. The mother delivered an abnormal male infant with generalized fixed joint contractures, rigid and shiny skin, skin laceration around the neck, a rounded and opened mouth, and palpebral conjunctival eversion. The subsequent pregnancy was also complicated by spontaneous complete chorioamniotic membrane separation, oligohydramnios, and fetal growth restriction at 26 + 3 weeks of gestation. A immaturely born second baby also carried multiple anomalies similar to those of the first. Both infants died shortly after birth. After microscopic examination of the skin, we diagnosed the infant as restrictive dermopathy. CONCLUSIONS: Complete separation of the chorion-amnion membrane may be regarded as a serious prenatal condition. Restrictive dermopathy or skin disorders caused by defects in collagen or elastic tissue metabolism may be one of the many causes of chorion-amnion separation.
Young Nam Kim; Dae Hoon Jeong; Su Jeon Jeong; Moon Su Sung; Mi Seon Kang; Ki Tae Kim
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  27     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-04     Completed Date:  2007-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  352-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 John Wiley & Sons, Ltd.
Department of Obstetrics and Gynecology, Busan Paik Hospital, College of Medicine, Inje University, Busanjin-gu, Korea.
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MeSH Terms
Amnion / abnormalities*,  pathology,  ultrasonography
Chorion / abnormalities*,  pathology,  ultrasonography
Fetal Death
Fetal Membranes, Premature Rupture
Infant, Newborn
Pregnancy Complications*
Ultrasonography, Prenatal

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