| Complete atrioventricular block and ventricular tachyarrhythmia associated with donepezil. | |
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MedLine Citation:
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PMID: 16858101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Donepezil is a reversible inhibitor of acetylcholinesterase. Its commonest adverse events are nausea, diarrhoea, malaise, dizziness, and insomnia. Symptomatic cardiac rhythm disturbances associated with the use of donepezil are extremely unusual. An 82 year old patient with Alzheimer's disease (AD) developed complete atrioventricular block and ventricular tachyarrhythmia 1 month after starting treatment with donepezil, and was admitted to the emergency department because of dizziness and syncope. Immediately after admission, a temporary ventricular pacing catheter was placed in the right ventricle. Rhythm was observed to return to a normal sinus rhythm on the fourth day after implantation. Treatment of AD with cholinesterase inhibitors carries a risk of cardiac disturbances. In addition to sinusal bradycardia, it may lead to such major dysrhythmias as complete atrioventricular block and ventricular tachyarrhythmia, as in our case. In this report, we describe symptomatic complete atrioventricular block and ventricular tachyarrhythmia associated with the use of donepezil. |
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Authors:
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T Suleyman; P Tevfik; G Abdulkadir; S Ozlem |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Emergency medicine journal : EMJ Volume: 23 ISSN: 1472-0213 ISO Abbreviation: Emerg Med J Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-21 Completed Date: 2007-02-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100963089 Medline TA: Emerg Med J Country: England |
Other Details:
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Languages: eng Pagination: 641-2 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Karadeniz Technical University School of Medicine, 61080 Trabzon, Turkey. suleymanturedi@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Alzheimer Disease / drug therapy Cardiac Pacing, Artificial Cholinesterase Inhibitors / adverse effects* Electrocardiography Heart Block / chemically induced*, diagnosis, therapy Humans Indans / adverse effects* Male Piperidines / adverse effects* Tachycardia, Ventricular / chemically induced*, diagnosis, therapy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 0/Indans; 0/Piperidines; 120011-70-3/donepezil |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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