Document Detail


Complete response and long-term survival in malignant pleural mesothelioma: case report.
MedLine Citation:
PMID:  22493390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CASE REPORT: At the beginning of 2007, a 26-year-old Peruvian woman was admitted to the hospital referring breathlessness and other non-specific symptoms such as fever and weight loss. After the diagnosis of pleural mesothelioma by thoracoscopic talc insufflation, combined with pleural biopsy, and total body computed tomographic scan, the patient underwent two cycles of neoadjuvant chemotherapy with pemetrexed (500 mg/m(2)) and cisplatin (75 mg/m(2)), followed by an extra-pleural pneumonectomy. After 6 months, the patient was treated with three-dimensional external beam radiation therapy to the left hemithorax. Computed tomographic scans, performed after the ending of the radiotherapy, integrated with positron-emission tomography, were all negative for neoplastic pathology. The patient remains in good health and free from recurrence at four years.
CONCLUSION: This clinical case shows a disease-free survival interval of 4 years for malignant pleural mesothelioma. A good staging system and a combined treatment, involving surgery, neoadjuvant chemotherapy and adjuvant radiation therapy, represent a useful strategy not only to contain local disease progression, but even to increase disease-free survival in pleural mesothelioma.
Authors:
Silvia Takanen; Blerina Resuli; Vanessa Graziano; Alessandro Parisi; Roberto Lisi; Nicola Raffetto; Vincenzo Tombolini
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-11     Completed Date:  2012-05-24     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1485-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Cisplatin / administration & dosage
Combined Modality Therapy
Disease-Free Survival*
Female
Glutamates / administration & dosage
Guanine / administration & dosage,  analogs & derivatives
Humans
Mesothelioma / drug therapy,  surgery,  therapy*
Pleural Neoplasms / drug therapy,  surgery,  therapy*
Positron-Emission Tomography
Treatment Outcome
Chemical
Reg. No./Substance:
0/Glutamates; 04Q9AIZ7NO/pemetrexed; 5Z93L87A1R/Guanine; Q20Q21Q62J/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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