Document Detail


Complementation of vif-defective human immunodeficiency virus type 1 by primate, but not nonprimate, lentivirus vif genes.
MedLine Citation:
PMID:  7769676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The productive infection of many susceptible human cells, including lymphocytes and macrophages derived from peripheral blood, by the pathogenic lentivirus human immunodeficiency virus type 1 requires expression of the virally encoded vif (for virion infectivity factor) gene. Interestingly, this gene appears to have been conserved among all of the lentiviruses of primates and almost all of the lentiviruses of nonprimates. Using T cells constitutively expressing vif genes derived from diverse sources and virus replication assays, we show that the vif gene of a second primate lentivirus, simian immunodeficiency virus from macaques, complements vif-defective human immunodeficiency virus type 1 but that those of three distinct nonprimate lentiviruses do not. Although the molecular basis for Vif function has yet to be defined, the potential implications of this noted restriction of vif complementarity are discussed.
Authors:
J H Simon; T E Southerling; J C Peterson; B E Meyer; M H Malim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of virology     Volume:  69     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-07-06     Completed Date:  1995-07-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4166-72     Citation Subset:  IM; X    
Affiliation:
Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia 19104-6148, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Defective Viruses / genetics*
Genes, vif*
Genetic Complementation Test
HIV-1 / genetics*
Humans
Mice
Mice, Inbred BALB C
Simian immunodeficiency virus / genetics*
Virus Replication
Grant Support
ID/Acronym/Agency:
2-T32-AI07325-06/AI/NIAID NIH HHS
Comments/Corrections

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