Document Detail

Complementation between two temperature-sensitive mammalian cell mutants, each defective in the G1 phase of the cell cycle.
MedLine Citation:
PMID:  605389     Owner:  NLM     Status:  MEDLINE    
Two mammalian temperature-sensitive (ts) G1 cell cycle mutants of different species origin (Syrian hamster and mouse) have been tested for complementation using somatic cell hybrid analysis. All hamster-mouse hybrid clones tested were found to exhibit normal growth properties at the restrictive temperature, while neither mutant alone was capable of normal growth at this temperature. The two mutant lines therefore complement for growth in a somatic cell hybrid and most likely represent ts lesions in different cellular functions specific to the G1 phase of the cell cycle.
R M Liskay; H K Meiss
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Somatic cell genetics     Volume:  3     ISSN:  0098-0366     ISO Abbreviation:  Somatic Cell Genet.     Publication Date:  1977 May 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506054     Medline TA:  Somatic Cell Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  IM    
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MeSH Terms
Cell Cycle*
Cell Line
Genetic Complementation Test
Hybrid Cells* / cytology

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