| Complementation analysis of ataxia-telangiectasia. | |
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MedLine Citation:
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PMID: 3864936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a number of laboratories genetic analysis of ataxia-telangiectasia (AT) has been performed by studying the expression of the AT phenotype in fused somatic cells or mixtures of cell-free extracts from different patients. Complementation of the defective response to ionizing radiation was observed frequently, considering four different parameters for radiosensitivity in AT. The combined results from studies on cultured fibroblasts or lymphoblastoid cells from 17 unrelated families revealed the presence of at least four and possibly nine complementation groups. These findings suggest that there is an extensive genetic heterogeneity in AT. More extensive studies are needed for an integration of these data and to provide a set of genetically characterized cell strains for future research of the AT genetic defect. |
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Authors:
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N G Jaspers; R B Painter; M C Paterson; C Kidson; T Inoue |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Kroc Foundation series Volume: 19 ISSN: 0361-0489 ISO Abbreviation: Kroc Found Ser Publication Date: 1985 |
Date Detail:
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Created Date: 1986-01-16 Completed Date: 1986-01-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7611160 Medline TA: Kroc Found Ser Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 147-62 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ataxia Telangiectasia
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genetics* Cells, Cultured Chromosomes, Human / radiation effects DNA Repair / radiation effects DNA Replication / radiation effects Fibroblasts Genetic Complementation Test Humans Lymphocytes Radiation Tolerance |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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