Document Detail

Complementation analysis of ataxia-telangiectasia.
MedLine Citation:
PMID:  3864936     Owner:  NLM     Status:  MEDLINE    
In a number of laboratories genetic analysis of ataxia-telangiectasia (AT) has been performed by studying the expression of the AT phenotype in fused somatic cells or mixtures of cell-free extracts from different patients. Complementation of the defective response to ionizing radiation was observed frequently, considering four different parameters for radiosensitivity in AT. The combined results from studies on cultured fibroblasts or lymphoblastoid cells from 17 unrelated families revealed the presence of at least four and possibly nine complementation groups. These findings suggest that there is an extensive genetic heterogeneity in AT. More extensive studies are needed for an integration of these data and to provide a set of genetically characterized cell strains for future research of the AT genetic defect.
N G Jaspers; R B Painter; M C Paterson; C Kidson; T Inoue
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kroc Foundation series     Volume:  19     ISSN:  0361-0489     ISO Abbreviation:  Kroc Found Ser     Publication Date:  1985  
Date Detail:
Created Date:  1986-01-16     Completed Date:  1986-01-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7611160     Medline TA:  Kroc Found Ser     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-62     Citation Subset:  IM    
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MeSH Terms
Ataxia Telangiectasia / genetics*
Cells, Cultured
Chromosomes, Human / radiation effects
DNA Repair / radiation effects
DNA Replication / radiation effects
Genetic Complementation Test
Radiation Tolerance

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