Document Detail

Complementary techniques for unbiased stereology of brain ultrastructure.
MedLine Citation:
PMID:  14599105     Owner:  NLM     Status:  MEDLINE    
Estimating synaptic density is central to any examination of synaptic change. Barring techniques involving exhaustive sectioning, the traditional method for this estimation is the double dissector technique, which derives a ratio of synapses per neuron. This ratio, however, may not always equate to an absolute number of synapses. In contrast, the unbiased brick, while free of these problems, is limited by changes in reference space and cannot provide information on synaptic connectivity. Thus, the ideal analysis is to derive both synaptic measures. When these measures agree, one can discount changes in extraneous factors influencing synaptic counts.
Diano F Marrone; Janelle C LeBoutillier; Ted L Petit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of electron microscopy     Volume:  52     ISSN:  0022-0744     ISO Abbreviation:  J Electron Microsc (Tokyo)     Publication Date:  2003  
Date Detail:
Created Date:  2003-11-05     Completed Date:  2003-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7611157     Medline TA:  J Electron Microsc (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  425-8     Citation Subset:  IM    
Department of Psychology and Program in Neuroscience, University of Toronto, 1265 Military Trail, Toronto, ON M1C 1A4, Canada.
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MeSH Terms
Brain / ultrastructure*
Dissection / methods
Microscopy, Electron / methods
Neurons / ultrastructure*
Neuropil / ultrastructure
Synapses / ultrastructure*

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