Document Detail

Complementary medicines in psychiatry: review of effectiveness and safety.
MedLine Citation:
PMID:  16449696     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The use of complementary medicines in those with mental health problems is well documented. However, their effectiveness is often not established and they may be less harmless than commonly assumed. AIMS: To review the complementary medicines routinely encountered in psychiatric practice, their effectiveness, potential adverse effects and interactions. METHOD: Electronic and manual literature search on the effectiveness and safety of psychotropic complementary medicines. RESULTS: Potentially useful substances include ginkgo and hydergine as cognitive enhancers, passion flower and valerian as sedatives, St John's wort and s-adenosylmethionine as antidepressants, and selenium and folate to complement antidepressants. The evidence is less conclusive for the use of omega-3 fatty acids as augmentation treatment in schizophrenia, melatonin for tardive dyskinesia and 18-methoxycoronaridine, an ibogaine derivative, for the treatment of cocaine and heroin addiction. CONCLUSIONS: Systematic clinical trials are needed to test promising substances. Meanwhile, those wishing to take psychotropic complementary medicines require appropriate advice.
Ursula Werneke; Trevor Turner; Stefan Priebe
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  188     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-01     Completed Date:  2006-05-25     Revised Date:  2006-09-26    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  109-21     Citation Subset:  IM    
Division of Psychiatry, Homerton University Hospital, East Wing, Homerton Row, London E9 6SR, UK.
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MeSH Terms
Antidepressive Agents / therapeutic use
Antipsychotic Agents / therapeutic use
Cognition Disorders / drug therapy
Complementary Therapies / adverse effects,  methods*
Dementia / drug therapy
Dyskinesias / drug therapy
Ergoloid Mesylates / therapeutic use
Folic Acid / therapeutic use
Hypnotics and Sedatives / therapeutic use
Mental Disorders / therapy*
Nootropic Agents / therapeutic use
Phytotherapy / methods
Plant Preparations / therapeutic use
S-Adenosylmethionine / therapeutic use
Selenium / therapeutic use
Substance-Related Disorders / drug therapy
Reg. No./Substance:
0/Antidepressive Agents; 0/Antipsychotic Agents; 0/Hypnotics and Sedatives; 0/Nootropic Agents; 0/Plant Preparations; 29908-03-0/S-Adenosylmethionine; 59-30-3/Folic Acid; 7782-49-2/Selenium; 8067-24-1/Ergoloid Mesylates
Comment In:
Br J Psychiatry. 2006 Jun;188:587; author reply 587-8   [PMID:  16738355 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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