| Complementary information from magnetic resonance imaging and (18)F-fluoromisonidazole positron emission tomography in the assessment of the response to an antiangiogenic treatment in a rat brain tumor model. | |
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MedLine Citation:
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PMID: 21843775 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: No direct proof has been brought to light in a link between hypoxic changes in glioma models and the effects of antiangiogenic treatments. Here, we assessed the sensitivity of the detection of hypoxia through the use of (18)F-fluoromisonidazole positron emission tomography ([(18)F]-FMISO PET) in response to the evolution of the tumor and its vasculature. METHODS: Orthotopic glioma tumors were induced in rats after implantation of C6 or 9L cells. Sunitinib was administered from day (D) 17 to D24. At D17 and D24, multiparametric magnetic resonance imaging was performed to characterize tumor growth and vasculature. Hypoxia was assessed by [(18)F]-FMISO PET. RESULTS: We showed that brain hypoxic volumes are related to glioma volume and its vasculature and that an antiangiogenic treatment, leading to an increase in cerebral blood volume and a decrease in vessel permeability, is accompanied by a decrease in the degree of hypoxia. CONCLUSIONS: We propose that [(18)F]-FMISO PET and multiparametric magnetic resonance imaging are pertinent complementary tools in the evaluation of the effects of an antiangiogenic treatment in glioma. |
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Authors:
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Samuel Valable; Edwige Petit; Simon Roussel; Léna Marteau; Jérôme Toutain; Didier Divoux; Franck Sobrio; Jérôme Delamare; Louisa Barré; Myriam Bernaudin |
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Publication Detail:
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Type: Journal Article Date: 2011-04-21 |
Journal Detail:
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Title: Nuclear medicine and biology Volume: 38 ISSN: 1872-9614 ISO Abbreviation: Nucl. Med. Biol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9304420 Medline TA: Nucl Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 781-93 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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CERVOxy group, UMR 6232 CI-NAPS. CNRS, Université de Caen Basse-Normandie, Université Paris-Descartes, CEA. GIP CYCERON, Bd Henri Becquerel, BP5229, 14074 CAEN cedex, France. |
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