| Complementary acupuncture in Parkinson's disease: a spect study. | |
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MedLine Citation:
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PMID: 20199208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied cerebral effects of complementary acupuncture in Parkinson's disease using single photon emission computed tomography (SPECT) measures of 99mTc-ECD and 99mTc-TRODAT-4, before and after five weeks of treatment. Ten patients were randomly assigned to receive levodopa alone (controls) or levodopa and complementary scalp electro-acupuncture. Before treatment, no hemispheric regional cerebral blood flow (rCBF) differences were found, whereas striatal dopamine transporter (DAT) activity was lower in the most affected hemisphere. Treatment with levodopa alone did not change rCBF, whereas it increased basal ganglion DAT activity in the most affected hemisphere. Patients who received levodopa and complementary acupuncture had increased rCBF in the frontal lobe, the occipital lobe, the basal ganglion, and the cerebellum in the most affected hemisphere as compared to baseline, but there were no changes in basal ganglia DAT levels. Thus, complementary acupuncture treatment in Parkinson's disease may affect rCBF but not basal ganglion DAT. |
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Authors:
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Yong Huang; Xuemei Jiang; Ying Zhuo; Gustav Wik |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The International journal of neuroscience Volume: 120 ISSN: 1563-5279 ISO Abbreviation: Int. J. Neurosci. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-04 Completed Date: 2010-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 150-4 Citation Subset: IM |
Affiliation:
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School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China. nanfanglihuang@163.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acupuncture Therapy* Aged Antiparkinson Agents / therapeutic use Basal Ganglia / radionuclide imaging Cerebrovascular Circulation / physiology Combined Modality Therapy Data Interpretation, Statistical Dopamine Plasma Membrane Transport Proteins / metabolism Female Functional Laterality / physiology Humans Image Processing, Computer-Assisted Levodopa / therapeutic use Male Middle Aged Neostriatum / metabolism Parkinson Disease / drug therapy, radionuclide imaging*, therapy* Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Dopamine Plasma Membrane Transport Proteins; 0/Levodopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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