Document Detail


Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease.
MedLine Citation:
PMID:  9448574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used PET with the tracers [18F]fluorodeoxyglucose (FDG), [18F]fluorodopa (FDOPA) and [11C]raclopride (RACLO) to study striatal glucose and dopa metabolism, and dopamine D2 receptor binding, respectively, in nine patients with multiple system atrophy. Ten patients with classical Parkinson's disease were investigated with the same three PET tracers' and three separate groups, each of 10 healthy subjects, served as control populations. We found that striatal FDOPA values separated all healthy subjects from patients with parkinsonism but they were not useful in distinguishing multiple system atrophy from Parkinson's disease. Conversely, striatal RACLO as well as FDG values discriminated all multiple system atrophy from Parkinson's disease patients as well as from healthy control subjects. Metabolic and receptor binding decrements in the putamen of multiple system atrophy patients were significantly correlated. Stepwise regression analysis revealed that a linear combination of putamen RACLO and FDOPA values accurately predicted clinical measures of disease severity in the multiple system atrophy group. Our findings suggest that striatal FDG and particularly RACLO are sensitive and effective measures of striatal function and may help characterizing patients with multiple system atrophy. In contrast, FDOPA measurements are accurate in detecting abnormalities of the nigrostriatal dopaminergic system but may not distinguish among different forms of parkinsonism.
Authors:
A Antonini; K L Leenders; P Vontobel; R P Maguire; J Missimer; M Psylla; I Günther
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  120 ( Pt 12)     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-02-17     Completed Date:  1998-02-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2187-95     Citation Subset:  AIM; IM    
Affiliation:
PET Department, Paul Scherrer Institute, Villigen, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Carbon Radioisotopes / diagnostic use,  pharmacokinetics
Caudate Nucleus / metabolism,  radiography
Corpus Striatum / metabolism*,  radiography
Diagnosis, Differential
Dihydroxyphenylalanine / analogs & derivatives,  diagnostic use,  pharmacokinetics
Female
Fluorine Radioisotopes / diagnostic use,  pharmacokinetics
Fluorodeoxyglucose F18 / diagnostic use,  pharmacokinetics
Humans
Hypotension, Orthostatic
Male
Middle Aged
Multiple System Atrophy / metabolism,  radiography*
Neurons / metabolism*,  radiography
Parkinson Disease / metabolism,  radiography*
Putamen / metabolism,  radiography
Raclopride
Radiopharmaceuticals / diagnostic use,  pharmacokinetics
Receptors, Dopamine D2 / analysis,  metabolism*
Regression Analysis
Salicylamides / diagnostic use,  pharmacokinetics
Tomography, Emission-Computed
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Fluorine Radioisotopes; 0/Radiopharmaceuticals; 0/Receptors, Dopamine D2; 0/Salicylamides; 63-84-3/Dihydroxyphenylalanine; 63503-12-8/Fluorodeoxyglucose F18; 75290-51-6/fluorodopa F 18; 84225-95-6/Raclopride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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