Document Detail

Complementary foods fortified with micronutrients prevent iron deficiency and anemia in Vietnamese infants.
MedLine Citation:
PMID:  20980657     Owner:  NLM     Status:  MEDLINE    
To investigate whether an intervention including micronutrient-fortified complementary foods can improve iron status, we conducted a randomized controlled trial in 5-mo-old Vietnamese infants (n = 246). Villages (n = 29) were randomly divided into those receiving instant flour (FF) or a food complement (FC) both fortified with micronutrients or nothing [control (C)]. FF and FC infants received daily for 6 mo at least 2 meals of fortified complementary foods. Micronutrient status was assessed by measurement of hemoglobin (Hb) and plasma ferritin (PF), transferrin receptor, zinc, and retinol. Final Hb (mean ± SD) was higher in the FF (112.5 ± 8.0 g/L) and FC (114.0 ± 7.0 g/L) groups compared with C (109.0 ± 8.0 g/L; P = 0.006). PF (geometric mean [95% CI]) was also higher in FF (19.8 μg/L [17.5-22.3]) and FC (20.8 μg/L [18.3-23.6]) compared with C (11.1 μg/L [9.8-12.5]; P < 0.0001). Anemia prevalence decreased more in the FC group (-43.6%) compared with C (-10.3%; P = 0.006). The change in prevalence of PF < 12 μg/L was different in the FF (-16.4%) and FC (-6.7%) groups compared with C (+30.4%; P < 0.01). Endpoint prevalence of iron deficiency (ID) and ID anemia (IDA) were lower in the FF (13.4 and 6.7%, respectively) and FC (15.2 and 3.8%) groups compared with C (57.5 and 37.5%) (P < 0.0001). Retinol and zinc concentrations did not differ among groups, but endpoint prevalence of zinc deficiency was lower in FF infants (36.1%) than in C infants (52.9%; P = 0.04). Micronutrient-fortified complementary foods significantly improved iron status and decreased the prevalence of anemia, ID, and IDA in Vietnamese infants and can be an important tool to reduce ID in infancy in developing countries.
Pham Van Phu; Nguyen Van Hoan; Bertrand Salvignol; Serge Treche; Frank Tammo Wieringa; Nguyen Cong Khan; Pham Duy Tuong; Jacques Berger
Related Documents :
1714697 - Iron fortification of infant milk formula: the effect on iron status and immune function.
17465987 - Indices of iron deficiency and anaemia in bedouin and jewish toddlers in southern israel.
16424127 - Risk of infant anemia is associated with exclusive breast-feeding and maternal anemia i...
15369607 - Predictors of pregnancy and postpartum haemoglobin concentrations in low-income women.
6617307 - Infant perception of correlations among attributes.
24858107 - The role of the input on the development of the lc bias: a crosslinguistic comparison.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-10-27
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-30     Revised Date:  2011-01-25    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2241-7     Citation Subset:  IM    
Hanoi Medical University, Dong Da, Hanoi, Vietnam.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anemia, Iron-Deficiency / epidemiology,  prevention & control*
Food, Fortified*
Infant Food*
Micronutrients / administration & dosage*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Web-enabled and improved software tools and data are needed to measure nutrient intakes and physical...
Next Document:  Utilization of iron from an animal-based iron source is greater than that of ferrous sulfate in preg...