Document Detail

Complementability of temperature-sensitive adenovirus mutants with extracts of urogenital tumour cells.
MedLine Citation:
PMID:  3448879     Owner:  NLM     Status:  MEDLINE    
Complementation of two temperature-sensitive (ts) mutants of adenovirus type 5 was attempted with tumour extract in HEp-2 cell cultures at permissive and restrictive temperature. Both ts mutants were successfully complemented with adenovirus gene products extracted from bladder and kidney carcinoma cells. The percentage incidence of complementation appeared to be higher with extracts obtained from female patients than with those obtained from males. The same gene sequences may occur in penile carcinoma cells and in bladder carcinoma cells showing the early signs of malignization. Extracts of seminoma cells and of cells from prostatic hypertrophies contained adenovirus genes less frequently; infectious virus was never obtained from them. The same applies to cells from the non-tumourous ("control") patients tested. The old age of the patients and some properties of the tumours examined suggest that hormonal changes may contribute to adenovirus gene expression and, indirectly, to the malignant process and its continuity.
J Ongrádi; J Farkas; S Csata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta microbiologica Hungarica     Volume:  34     ISSN:  0231-4622     ISO Abbreviation:  Acta Microbiol. Hung.     Publication Date:  1987  
Date Detail:
Created Date:  1988-05-27     Completed Date:  1988-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8400270     Medline TA:  Acta Microbiol Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  187-96     Citation Subset:  IM    
Institute of Microbiology, Semmelweis University Medical School, Budapest, Hungary.
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MeSH Terms
Adenoviruses, Human / genetics*,  physiology
Cell Line
Genes, Viral*
Genetic Complementation Test
Kidney Neoplasms / microbiology
Middle Aged
Penile Neoplasms / microbiology
Prostatic Neoplasms / microbiology
Sex Factors
Testicular Neoplasms / microbiology
Urinary Bladder Neoplasms / microbiology
Urogenital Neoplasms / microbiology*
Viral Proteins / genetics*
Virus Replication
Reg. No./Substance:
0/Viral Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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