Document Detail

Complement split products C3a and C4a are early markers of acute lyme disease in tick bite patients in the United States.
MedLine Citation:
PMID:  18270493     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Current laboratory markers do not readily detect acute Lyme disease. We assessed the utility of complement and its split products as markers of Lyme disease in patients shortly after a tick bite. METHODS: Thirty-one consecutive acute Lyme disease patients, 14 with and 17 without erythema migrans (EM) skin rash, seen by a physician within 96 h of a tick bite were matched with 24 consecutive tick bite patients without Lyme disease symptoms and 46 healthy control subjects. Complement and split products measured included factor B, Bb, C4, C3c, C3a(des Arg), C4a(des Arg), C1q- and C3d-containing immune complexes, and C2. RESULTS: C2, C4, C3 and factor B levels were within normal ranges in all groups. C3a and C4a levels were significantly higher in acute Lyme disease patients than in tick bite and healthy control groups (both p < 0.001). All acute Lyme disease patients, regardless of EM, had elevated levels of C3a or C4a. Few tick bite controls had elevated levels of C3a (2/20) or C4a (5/24) and only 1 of the healthy control subjects had elevated C3a (0/46) or C4a (1/32). CONCLUSIONS: These findings suggest that C3a and C4a may be useful markers of Lyme disease in patients seen shortly after tick bite, even in those without EM.
Ritchie C Shoemaker; Patricia C Giclas; Chris Crowder; Dennis House; M Michael Glovsky
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Publication Detail:
Type:  Journal Article     Date:  2008-02-13
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  146     ISSN:  1423-0097     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  255-61     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel
Center for Research on Biotoxin Associated Illnesses, Pocomoke, Md., USA.
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MeSH Terms
Borrelia burgdorferi / immunology*
Complement Activation / immunology
Complement C3a / analysis,  immunology*
Complement C4a / analysis,  immunology*
Erythema Chronicum Migrans / immunology
Insect Bites and Stings / immunology
Lyme Disease / diagnosis,  immunology*,  microbiology
Middle Aged
Statistics, Nonparametric
Reg. No./Substance:
80295-42-7/Complement C3a; 80295-49-4/Complement C4a

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