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Complement split product C4d deposition in placenta in systemic lupus erythematosus and pregnancy-induced hypertension.
MedLine Citation:
PMID:  23530559     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Systemic lupus erythematosus (SLE) and pregnancy-induced hypertension (PIH) are related to premature delivery and intrauterine growth restriction (IUGR), and share histological findings of the placenta. Association with complement dysregulation has been reported in pregnancy for both disorders. The purpose of this study was to investigate the utility of C4d immunohistochemistry for placentas with SLE- and PIH-associated pregnancy. C4d staining was performed on paraffin-embedded tissue of placentas from 26 patients with SLE, 26 with PIH, and 25 control cases. We used the H-score with a range of 0-300 for the evaluation of C4d immunoreactivity. Placentas of SLE and PIH cases showed a higher H-score than control cases (average, SLE, 38.3 (P < 0.05); PIH, 17.8; control, 1.68), with linear staining on the membrane of syncytiotrophoblast. C4d-high groups comprised 50% (12/26) of SLE and 35% (9/26) of PIH cases, with H-scores ranging 14-270 and 15-170. C4d-high groups were significantly associated with low-placental weights and low birth weight in both SLE and PIH (P < 0.05), and lower gestational age (P < 0.05) in PIH cases. These results suggest that C4d might be utilized as a biomarker evaluating the subsequent risk for IUGR and disease control during the gestation period in these patients.
Authors:
Sachiko Minamiguchi; Yoshiki Mikami; Naoki Nakajima; Adeeb Salah; Eiji Kondoh; Keiji Tatsumi; Ikuo Konishi; Hironori Haga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  63     ISSN:  1440-1827     ISO Abbreviation:  Pathol. Int.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  150-7     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. Pathology International © 2013 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.
Affiliation:
Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
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