Document Detail

Complement split product C4d deposition in placenta in systemic lupus erythematosus and pregnancy-induced hypertension.
MedLine Citation:
PMID:  23530559     Owner:  NLM     Status:  In-Data-Review    
Systemic lupus erythematosus (SLE) and pregnancy-induced hypertension (PIH) are related to premature delivery and intrauterine growth restriction (IUGR), and share histological findings of the placenta. Association with complement dysregulation has been reported in pregnancy for both disorders. The purpose of this study was to investigate the utility of C4d immunohistochemistry for placentas with SLE- and PIH-associated pregnancy. C4d staining was performed on paraffin-embedded tissue of placentas from 26 patients with SLE, 26 with PIH, and 25 control cases. We used the H-score with a range of 0-300 for the evaluation of C4d immunoreactivity. Placentas of SLE and PIH cases showed a higher H-score than control cases (average, SLE, 38.3 (P < 0.05); PIH, 17.8; control, 1.68), with linear staining on the membrane of syncytiotrophoblast. C4d-high groups comprised 50% (12/26) of SLE and 35% (9/26) of PIH cases, with H-scores ranging 14-270 and 15-170. C4d-high groups were significantly associated with low-placental weights and low birth weight in both SLE and PIH (P < 0.05), and lower gestational age (P < 0.05) in PIH cases. These results suggest that C4d might be utilized as a biomarker evaluating the subsequent risk for IUGR and disease control during the gestation period in these patients.
Sachiko Minamiguchi; Yoshiki Mikami; Naoki Nakajima; Adeeb Salah; Eiji Kondoh; Keiji Tatsumi; Ikuo Konishi; Hironori Haga
Related Documents :
8990629 - Sideroblastic anemia recurring during two pregnancies.
24817599 - First-trimester hand measurements in euploid and aneuploid human foetuses using virtual...
3370919 - 2,3-diphosphoglycerate in normal, anaemic and transfused human fetuses.
113979 - The role of fetal movements assessment in cases of severe rh immunized patients.
8507469 - Structure and composition of stereocilia cross-links in normal and hydropic cochleas of...
2216269 - Ongoing fetomaternal hemorrhage treated by serial fetal intravascular transfusions.
24184339 - Term induction of labor and subsequent preterm birth.
6191039 - The ultrasonographic spectrum of fetal omphalocele.
16026919 - Low psychosocial resources during early pregnancy are not associated with prolonged lab...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  63     ISSN:  1440-1827     ISO Abbreviation:  Pathol. Int.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  150-7     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. Pathology International © 2013 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.
Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinicopathological features of acute megakaryoblastic leukaemia: Relationship between fibrosis and ...
Next Document:  POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine mark...