| Complement-mediated leucoembolization: a mechanism of tissue damage during extracorporeal perfusions, myocardial infarction and in shock--a review. | |
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MedLine Citation:
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PMID: 6359225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The complement (C) system evolved as a beneficial antimicrobial system. However, when activated during extracorporeal perfusion as with haemodialysis or cardiopulmonary bypass modest pulmonary dysfunction associated with granulocyte aggregation and embolization can occur. When C activation is massive and prolonged, as with severe sepsis, trauma, or acute pancreatitis, severe pulmonary damage which is recognized as shock lung, or adult respiratory distress syndrome, may occur. Since ulcerating atherosclerotic plaques can also activate C, a mechanism by which myocardial infarcts may extend during the first few hours after infarction is also implied. Therapeutic ramifications of these conclusions are evident. Thus, high doses of corticosteroids or of nonsteroidal anti-inflammatory agents such as ibuprofen share the ability to prevent aggregation and embolization of stimulated granulocytes to patent vessels downstream and also inhibit their production of toxic oxygen radicals. These properties suggest the use of these agents in myocardial infarction and shock states, particularly shock lung, and appropriate clinical trials are awaited with interest. |
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Authors:
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H S Jacob |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Quarterly journal of medicine Volume: 52 ISSN: 0033-5622 ISO Abbreviation: Q. J. Med. Publication Date: 1983 |
Date Detail:
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Created Date: 1984-01-07 Completed Date: 1984-01-07 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401027 Medline TA: Q J Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 289-96 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Animals Cardiopulmonary Bypass / adverse effects Cell Aggregation Complement Activation Complement C5 / immunology* Complement C5a Embolism / etiology* Granulocytes / immunology Humans Leukocytes / immunology* Myocardial Infarction / immunology* Renal Dialysis / adverse effects* Respiratory Distress Syndrome, Adult / drug therapy, etiology, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Complement C5; 80295-54-1/Complement C5a |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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