Document Detail

Complement-mediated leucoembolization: a mechanism of tissue damage during extracorporeal perfusions, myocardial infarction and in shock--a review.
MedLine Citation:
PMID:  6359225     Owner:  NLM     Status:  MEDLINE    
The complement (C) system evolved as a beneficial antimicrobial system. However, when activated during extracorporeal perfusion as with haemodialysis or cardiopulmonary bypass modest pulmonary dysfunction associated with granulocyte aggregation and embolization can occur. When C activation is massive and prolonged, as with severe sepsis, trauma, or acute pancreatitis, severe pulmonary damage which is recognized as shock lung, or adult respiratory distress syndrome, may occur. Since ulcerating atherosclerotic plaques can also activate C, a mechanism by which myocardial infarcts may extend during the first few hours after infarction is also implied. Therapeutic ramifications of these conclusions are evident. Thus, high doses of corticosteroids or of nonsteroidal anti-inflammatory agents such as ibuprofen share the ability to prevent aggregation and embolization of stimulated granulocytes to patent vessels downstream and also inhibit their production of toxic oxygen radicals. These properties suggest the use of these agents in myocardial infarction and shock states, particularly shock lung, and appropriate clinical trials are awaited with interest.
H S Jacob
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Quarterly journal of medicine     Volume:  52     ISSN:  0033-5622     ISO Abbreviation:  Q. J. Med.     Publication Date:  1983  
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0401027     Medline TA:  Q J Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  289-96     Citation Subset:  IM    
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Cardiopulmonary Bypass / adverse effects
Cell Aggregation
Complement Activation
Complement C5 / immunology*
Complement C5a
Embolism / etiology*
Granulocytes / immunology
Leukocytes / immunology*
Myocardial Infarction / immunology*
Renal Dialysis / adverse effects*
Respiratory Distress Syndrome, Adult / drug therapy,  etiology,  immunology*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Complement C5; 80295-54-1/Complement C5a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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