Document Detail

Complement-mediated cytolysis and azidothymidine are synergistic in HIV-1 suppression.
MedLine Citation:
PMID:  9488159     Owner:  NLM     Status:  MEDLINE    
Some normal human sera contain a natural IgM antibody against gangliotetraose and GM2 which is capable of initiating complement-mediated cytolysis of HIV-1-infected cells. A potent cytolytic serum (lytic serum) harboring this antibody also caused lysis of HIV-1 virions. When lytic serum was added to a mixed culture of HIV-infected cells and naive cells at a ratio of 1:100, expansion of HIV-1 infection was postponed by 1 week. Furthermore, the co-presence of both the lytic serum and azidothymidine continued to significantly suppress infection, even after 4 weeks of cultivation.
H Okada; X Wu; N Okada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International immunology     Volume:  10     ISSN:  0953-8178     ISO Abbreviation:  Int. Immunol.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-07     Completed Date:  1998-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8916182     Medline TA:  Int Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM; X    
Department of Molecular Biology, Nagoya City University School of Medicine, Nagoya, Japan.
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MeSH Terms
Anti-HIV Agents / pharmacology*
Complement Hemolytic Activity Assay
Complement System Proteins / immunology*
Cytotoxicity, Immunologic
Drug Synergism
HIV Infections / therapy*
HIV-1 / drug effects
Immunoglobulin M / blood,  immunology
Virion / drug effects
Zidovudine / pharmacology*
Reg. No./Substance:
0/Anti-HIV Agents; 0/Immunoglobulin M; 30516-87-1/Zidovudine; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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