Document Detail

Complement levels and leucocyte phagocytosis in newborn babies.
MedLine Citation:
PMID:  15259926     Owner:  NLM     Status:  MEDLINE    
Newborn babies face higher risk of infection than adults, but the immunological basis of this observation is yet to be fully explained particularly in babies of different gestations and birth weights. Sixty-two (62) adults, 55 full-term babies, 18 low birth weight babies and 44 normal birth weight babies were considered for the study. B-lymphocytes and T-lymphocytes were enumerated by EAC-rosette and E-rosette respectively. Leucocyte migration and intracellular killing were assessed by percentage migration index (%M.I), percentage Candidacidal index (%C.I) and bacterial stimulated nitroblue tetrazolium (NBT) dye reduction index (%NBT) respectively. Also, serum levels of C3 and C5 were measured by single radial immuno-diffusion method. Percentage T cell, C3, C5, %NBT and %C.I were lowest in low birth weight babies but % B cell was lowest in full term babies while normal birth babies had least %M.I. The present study suggests that gestational age and birth weight affect different aspects of immune response.
O G Arinola; K A Obisesan; K Afolabi; L S Salimonu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  African journal of medicine and medical sciences     Volume:  32     ISSN:  0309-3913     ISO Abbreviation:  Afr J Med Med Sci     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-07-19     Completed Date:  2004-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801013     Medline TA:  Afr J Med Med Sci     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  401-4     Citation Subset:  IM    
Department of Chemical Pathology and Immunology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
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MeSH Terms
Age Factors
B-Lymphocytes / immunology*
Complement C3 / metabolism*
Complement C5 / metabolism*
Infant, Low Birth Weight
Infant, Newborn / immunology*
Lymphocyte Count
Neutrophils / immunology
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Complement C3; 0/Complement C5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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