Document Detail


Complement inhibition to treat myocardial infarction?
MedLine Citation:
PMID:  22696664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors describe the case of a middle-aged women who presented with an acute myocardial infarction due to thrombotic occlusion of angiographically normal coronary arteries. Coronary thrombosis was caused by a hypercoagulable state related to a haemolytic crisis of paroxysmal nocturnal haemoglobinuria and the patient was treated conservatively with antithrombotic agents. The clinical course was complicated by both severe bleeding and thrombotic complications and the patient eventually died of a massive intracerebral haemorrhage. The rapid occurrence of complications inhibited a timely administration of a specific treatment for complement-mediated haemolysis (eculizumab).
Authors:
Bernhard Gerber; Tatiana Kyburz; Walter H Reinhart; Piero O Bonetti; Georg Stussi
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-04-26
Journal Detail:
Title:  BMJ case reports     Volume:  2011     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2011  
Date Detail:
Created Date:  2012-06-14     Completed Date:  2013-09-06     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Antibodies, Monoclonal, Humanized / therapeutic use
Complement Inactivating Agents / therapeutic use
Coronary Angiography
Echocardiography
Fatal Outcome
Female
Hemoglobinuria, Paroxysmal / complications*,  drug therapy
Humans
Myocardial Infarction / diagnosis*,  etiology
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal, Humanized; 0/Complement Inactivating Agents; A3ULP0F556/eculizumab
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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