| Complement in Pregnancy: A Delicate Balance. | |
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MedLine Citation:
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PMID: 22925193 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The complement system is a key component of innate host defence that, under normal conditions, is responsible for the opsonization and destruction of potential pathogens. However, inappropriate or excessive activation of complement can have a detrimental effect on the host and has been implicated in the pathophysiology of numerous disease states. Recently, there has been increasing evidence for a role of the complement system and, in particular, the potent pro-inflammatory anaphylatoxin complement component 5a (C5a) in both normal and complicated pregnancy. The following review describes the results of in vitro, animal, and human clinical studies investigating the role of the complement system in healthy pregnancy, recurrent miscarriage, preterm birth, and preeclampsia. |
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Authors:
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Kerina J Denny; Trent M Woodruff; Stephen M Taylor; Leonie K Callaway |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-27 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: - ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia; School of Medicine, The University of Queensland, Brisbane, QLD, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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