Document Detail

Complement, granulocytes, and shock lung.
MedLine Citation:
PMID:  6517988     Owner:  NLM     Status:  MEDLINE    
Intravascular leukostasis in the pulmonary microvasculature is a cardinal early histologic finding in patients with shock lung. Identical leukostasis is also observed in patients undergoing extracorporeal hemodialysis with cellophane membrane dialyzers, and it has been documented that the accumulation of granulocyte plugs in the lung is mediated by complement activation triggered by dialyzer cellophane. The C5a-desarg so generated causes peripheral blood granulocytes to aggregate, and the aggregates so formed embolize to the lung, where they cause occlusion of the microvasculature and increased capillary leakage, manifested by interstitial and alveolar edema. In vitro studies suggest that this endothelial damage is mediated by hydrogen peroxide from the adherent granulocytes. Most importantly, a close correlation has been found between the presence of C5a-desarg in plasma and the subsequent onset of shock lung in patients after trauma, burns, and sepsis. As exemplified by hemodialysis leukopenia, C5a-desarg-mediated pulmonary leukostasis is a self-limiting process because of selective down-regulation of granulocyte receptors for C5a-desarg--a mechanism that primarily limits the lung damage associated with intravascular complement activation.
P R Craddock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  2     ISSN:  0735-6757     ISO Abbreviation:  Am J Emerg Med     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1985-03-21     Completed Date:  1985-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  78-81     Citation Subset:  IM    
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MeSH Terms
Complement C5 / analysis*
Complement C5a
Granulocytes / analysis*
Leukopenia / blood*,  physiopathology
Respiratory Distress Syndrome, Adult / blood*,  physiopathology
Grant Support
Reg. No./Substance:
0/Complement C5; 80295-54-1/Complement C5a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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