Document Detail

Complement genetic markers in schizophrenia: C3, BF and C6 polymorphisms.
MedLine Citation:
PMID:  1511994     Owner:  NLM     Status:  MEDLINE    
Polymorphic variants of C3, BF and C6 complement factors have been investigated in schizophrenic patients subdivided according to the existence or not of a family history of both schizophrenia and other psychiatric disorders. To analyze the contingency tables, besides the usual methods, log-linear models have been fitted. Significant associations have been found in the C3 system, with a decrease of C3*F in patients (contradicting previous findings), and in the BF system, with a decrease of FS phenotype among patients (confirming some previous results). No association has been found for the C6 polymorphism (in accordance to previous results). Therefore, the present findings only partially confirm previous results and do not clarify the relationship between complement genetic markers and schizophrenia, stressing some statistical difficulties.
L Fañanás; P Moral; M A Panadero; J Bertranpetit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human heredity     Volume:  42     ISSN:  0001-5652     ISO Abbreviation:  Hum. Hered.     Publication Date:  1992  
Date Detail:
Created Date:  1992-09-28     Completed Date:  1992-09-28     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0200525     Medline TA:  Hum Hered     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  162-7     Citation Subset:  IM    
Laboratory of Anthropology, Faculty of Biology, University of Barcelona, Spain.
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MeSH Terms
Complement C3 / genetics*
Complement C6 / genetics*
Complement Factor B / genetics*
Genetic Markers / genetics
Linear Models
Polymorphism, Genetic / genetics*
Schizophrenia / genetics*
Reg. No./Substance:
0/Complement C3; 0/Complement C6; 0/Genetic Markers; EC Factor B

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