Document Detail

Complement factor h polymorphism, inflammatory mediators, and retinal vessel diameters: the rotterdam study.
MedLine Citation:
PMID:  17591866     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Retinal venular dilatation is associated with systemic inflammation. The hypothesis for the current study was that larger retinal venular diameters are related to the His allele of the Tyr402His polymorphism in the complement factor H (CFH) gene, a major inhibitor of the complement pathway. Possible effect modification by smoking and inflammatory markers was examined. METHODS: This cross-sectional study was performed within the Rotterdam Study, a population-based study among elderly persons aged 55 years and older. The Tyr402His polymorphism of the CFH gene was genotyped in 5066 participants and retinal arteriolar and venular diameters were graded on digitized fundus transparencies. RESULTS: Genotype frequencies were 41% in TyrTyr, 45% in TyrHis, and 14% in HisHis carriers. The His(402) allele was associated with smaller rather than larger venular diameters (age- and sex-adjusted means and standard errors [in micrometers] were 222.5 +/- 0.45 for TyrTyr, 221.9 +/- 0.43 for TyrHis, and 220.6 +/- 0.78 for HisHis carriers; P-trend = 0.03). This association was apparent only in never-smokers and was not modified by the inflammatory markers erythrocyte sedimentation rate, leukocyte count, C-reactive protein, or fibrinogen. Adjustment for cardiovascular risk factors did not change results. No associations were found with arteriolar diameters. CONCLUSIONS: The findings do not support the hypothesis that the His(402) allele is related to larger retinal venular diameters. The association with smaller retinal venular diameters most likely is a chance finding, because it was present only among never-smokers and was not modified by inflammatory mediators of complement. These results suggest that the Tyr402His variant is not related to retinal venular diameters.
Frank Jan de Jong; M Kamran Ikram; Dominiek D G Despriet; André G Uitterlinden; Albert Hofman; Monique M B Breteler; Paulus T V M de Jong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  48     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-26     Completed Date:  2007-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3014-8     Citation Subset:  IM    
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Blood Sedimentation
C-Reactive Protein / metabolism
Complement Factor H / genetics
Cross-Sectional Studies
Fibrinogen / metabolism
Histidine / genetics
Inflammation Mediators / blood*
Middle Aged
Polymorphism, Genetic*
Prospective Studies
Retinal Vessels / pathology*
Reg. No./Substance:
0/Inflammation Mediators; 0/complement factor H, human; 71-00-1/Histidine; 80295-65-4/Complement Factor H; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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